지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.4
- 수록면
- 248 - 254 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Although cyclosporine (CsA) improves short-term renal graft outcomes, many paradigms reduce or withdraw this drug because of its nephrotoxicity. However, inadequate immunosuppression with azathioprine led to little success. We conducted a prospective study to define the prolonged effect of CsA reduction in stable renal transplant recipients with mycophenolate mofetil (MMF).
Methods: Thirty-nine primary renal transplant recipients were divided into two cohorts, the AZA (N=13) and the MMF cohort (N=26). Both cohorts were allowed to reduce the CsA dose up to 50% of baseline within 3 to 4 months of conversion to AZA or MMF. Graft function, clinical parameters, and adverse events were monitored for up to 3 years.
Results: Ccr gradually deteriorated in the AZA cohort, but was stable in the MMF cohort. There was no episode of acute rejection or graft loss observed in either cohort.
Conclusion: The CsA dose can be reduced in combination with MMF treatment in stable renal transplant recipients after 2 years of transplantation, resulting in beneficial effects on Ccr, lipid profiles, and blood pressure.
Methods: Thirty-nine primary renal transplant recipients were divided into two cohorts, the AZA (N=13) and the MMF cohort (N=26). Both cohorts were allowed to reduce the CsA dose up to 50% of baseline within 3 to 4 months of conversion to AZA or MMF. Graft function, clinical parameters, and adverse events were monitored for up to 3 years.
Results: Ccr gradually deteriorated in the AZA cohort, but was stable in the MMF cohort. There was no episode of acute rejection or graft loss observed in either cohort.
Conclusion: The CsA dose can be reduced in combination with MMF treatment in stable renal transplant recipients after 2 years of transplantation, resulting in beneficial effects on Ccr, lipid profiles, and blood pressure.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Nankivell BJ / 2004 / O'Connell PJ, Chapman JR, Allen RD. Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology / Transplantation 78 : 557 ~ 565
2. [학술지(정기간행물)] - Keogh A / 2004 / Calcineurin inhibitors in heart transplantation / J Heart Lung Transplant 23 : S202 ~ S206
3. [학술지(정기간행물)] - Bertani T / 1991 / Nature and extent of glomerular injury induced by cyclosporine in heart transplant patients / Kidney Int 40 : 243 ~ 250
4. [학술지(정기간행물)] - Ojo AO / 2000 / Mycophenolate mofetil reduces late renal allograft loss independent of acute rejection / Transplantation 69 : 2405 ~ 2409
5. [학술지(정기간행물)] - Meier-Kriesche HU / 2003 / Mycophenolate mofetil versus azathioprine therapy is associated with a significant protection against long-term renal allograft function deterioration / Transplantation 75 : 1341 ~ 1346
2. [학술지(정기간행물)] - Keogh A / 2004 / Calcineurin inhibitors in heart transplantation / J Heart Lung Transplant 23 : S202 ~ S206
3. [학술지(정기간행물)] - Bertani T / 1991 / Nature and extent of glomerular injury induced by cyclosporine in heart transplant patients / Kidney Int 40 : 243 ~ 250
4. [학술지(정기간행물)] - Ojo AO / 2000 / Mycophenolate mofetil reduces late renal allograft loss independent of acute rejection / Transplantation 69 : 2405 ~ 2409
5. [학술지(정기간행물)] - Meier-Kriesche HU / 2003 / Mycophenolate mofetil versus azathioprine therapy is associated with a significant protection against long-term renal allograft function deterioration / Transplantation 75 : 1341 ~ 1346
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A multicenter experience with generic mycophenolate mofetil conversion in stable liver transplant recipients
Annals of Surgical Treatment and Research
2014 .04
-
Mycophenolate Mofetil 부작용 발생에 미치는 요인 분석
한국임상약학회지
2010 .01
-
Mycophenolate Mofetil-Related Colitis - A Case Report -
Journal of Pathology and Translational Medicine
2010 .01
-
생체간이식에서 Tacrolimus와 Mycophenolate Mofetil (MMF)의 병합요법의 안정성
한국간담췌외과학회 학술대회지
2004 .10
-
Cyclosporine 용량을 줄이기 위한 Azathioprine과 MMF의 병합요법의 비교
대한외과학회 학술대회 초록집
2004 .10
-
Efficacy and Safety of Mycophenolate Mofetil in Children with Steroid Dependent Nephrotic Syndrome
Childhood Kidney Diseases
2015 .01
-
Prospective Clinical Trial of the Effect and Safety of Reduced Dose of Mycophenolate Mofetil with Tacrolimus Combination Immunosuppression in Living Donor Liver Transplant
한국간담췌외과학회 학술대회지
2010 .04
-
Clinical Pharmacology of Mycophenolic Acid as Immunosuppressant in Organ Transplaantation
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2005 .01
-
신장이식 환자에서 Cyclosporine의 적정 투여량
Annals of Surgical Treatment and Research
1994 .08
-
Cohort studies
대한외과학회 학술대회 초록집
2009 .11
-
Safety of reduced dose of mycophenolate mofetil combined with tacrolimus in living-donor liver transplantation
Clinical and Molecular Hepatology
2014 .01
-
Intra-individual variability of mycophenolic acid concentration according to renal function in liver transplant recipients receiving mycophenolate monotherapy
Annals of Hepato-Biliary-Pancreatic Surgery
2017 .02
-
Chronic Cyclosporine Nephrotoxicity: New Insights and Preventive Strategices
Yonsei Medical Journal
2004 .01
-
한국인 신장이식후 Cyclosporine 전혈중 농도에 관한 고찰
Annals of Surgical Treatment and Research
1986 .01
-
GI(Gastrointestinal)bleeding이 심한 IMT(Immune-mediated thrombocytopinia) 환자의 치료에서 MMF(mycophenolate mofetil)의 적용과 장기적인 관리
WITH CAP(COMPANION ANIMAL PRACTICE)
2018 .12
-
싸이클로스포린을 투여한 신장이식 환자에서의 신독성
Annals of Surgical Treatment and Research
1988 .06
-
신장이식 후 Mycophenolate Mofetil과 Steroid만을 사용한 유지면역억제치료
Annals of Surgical Treatment and Research
2003 .12
-
Effectiveness of Cyclosporine in a 10-year-old Girl with C3 Glomerulopathy
Childhood Kidney Diseases
2017 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
근치적 전립선적출술 후 요실금에 대한 케겔운동의 효과 : 무작위 대조군 실험연구의 체계적 문헌고찰
박성희
,
조윤수
,
곽미정
외 2명
성인간호학회지
2013
.04
신장 재이식 환자에서 종격동에 발생한 카포시 육종 : Sirolimus와 항암요법을 통한 임상적 경험
윤규종
,
김수진
,
박철재
외 5명
Annals of Surgical Treatment and Research
2009
.01
신이식 후 초기의 적절한 Tacrolimus 치료 농도
민상일
,
김성엽
,
안상현
외 4명
Annals of Surgical Treatment and Research
2010
.12
수은폭로 근로자의 조기 신기능 장해 지표로서의 요중 β-Galactosidase 활성도에 관한 연구
오연희
,
김광종
,
천병철
외 1명
대한직업환경의학회지
1995
.02
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2013-514-002693292