지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.8
- 수록면
- 96 - 102 (7page)
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초록· 키워드
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Purpose: The conventional prognostic factors for breast cancer reflect the early short-term prognosis. However, many of these factors cannot predict the long-term prognosis accurately. Therefore, this study evaluated the characteristics of breast cancer that would indicate the development of delayed recurrences after primary treatment.
Methods: Eight hundred and forty nine female breast cancer patients were divided into two groups, an early recurrent (within 5 years) and a late recurrent group (after 5 years). Each conventional prognostic factor including the histological grade (HG), nuclear grade (NG), lympho-vascular invasion (LVI), status of hormonal receptor, p53 and c-erbB2 were compared to identify any factor that would show significant difference.
Results: The overall recurrence rate was 14.2% (121/849), which was significantly higher in patients with a high TNM stage, high HG and NG, positive LVI, negative receptor status and expression of p53 (P＜0.05). The mean disease free interval was 28.2 months. In the recurred patients, 90.1% (109/121) recurred within 5 years, and 9.9% (12/121) recurred after 5 years of treatment. There was a similar distribution of most prognostic factors in the two groups (P＞0.05). However, the positive rate of the hormonal receptor was significantly higher in the late recurrent group (P=0.019). All these factors, except for c-erbB2 over-expression, were independent prognostic factors for a recurrence within 5 years (P＜0.05) but the significance of these factors disappeared after that time (P＞0.05).
Conclusion: The positive hormone receptor of breast cancer is a good early prognostic factor that can also predict late recurrences.
Methods: Eight hundred and forty nine female breast cancer patients were divided into two groups, an early recurrent (within 5 years) and a late recurrent group (after 5 years). Each conventional prognostic factor including the histological grade (HG), nuclear grade (NG), lympho-vascular invasion (LVI), status of hormonal receptor, p53 and c-erbB2 were compared to identify any factor that would show significant difference.
Results: The overall recurrence rate was 14.2% (121/849), which was significantly higher in patients with a high TNM stage, high HG and NG, positive LVI, negative receptor status and expression of p53 (P＜0.05). The mean disease free interval was 28.2 months. In the recurred patients, 90.1% (109/121) recurred within 5 years, and 9.9% (12/121) recurred after 5 years of treatment. There was a similar distribution of most prognostic factors in the two groups (P＞0.05). However, the positive rate of the hormonal receptor was significantly higher in the late recurrent group (P=0.019). All these factors, except for c-erbB2 over-expression, were independent prognostic factors for a recurrence within 5 years (P＜0.05) but the significance of these factors disappeared after that time (P＞0.05).
Conclusion: The positive hormone receptor of breast cancer is a good early prognostic factor that can also predict late recurrences.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Hayes DF / 1987 / CAF in metastatic breast cancer: standard therapy or another effective regimen? / J Clin Oncol 59 : 1497 ~ 1499
2. [학술지(정기간행물)] - Rosen PR / 1989 / A long-term follow-up study of survival in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma / J Clin Oncol 7 : 355 ~ 366
3. [학술지(정기간행물)] - Saphner T / 1996 / Annual hazard rates of recurrence for breast cancer after primary therapy / J Clin Oncol 14 : 2738 ~ 2746
4. [학술지(정기간행물)] - Langlands AO / 1979 / Long-term survival of patients with breast cancer: a study of the curability of the disease / Br Med J 2 : 1247 ~ 1251
5. [학술지(정기간행물)] - Gamel JW / 1988 / Interval-by-interval Cox model analysis of 3680 cases of intraocular melanoma shows a decline in the prognostic value of size and cell type over time after tumor excision / Cancer 61 : 574 ~ 579
2. [학술지(정기간행물)] - Rosen PR / 1989 / A long-term follow-up study of survival in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma / J Clin Oncol 7 : 355 ~ 366
3. [학술지(정기간행물)] - Saphner T / 1996 / Annual hazard rates of recurrence for breast cancer after primary therapy / J Clin Oncol 14 : 2738 ~ 2746
4. [학술지(정기간행물)] - Langlands AO / 1979 / Long-term survival of patients with breast cancer: a study of the curability of the disease / Br Med J 2 : 1247 ~ 1251
5. [학술지(정기간행물)] - Gamel JW / 1988 / Interval-by-interval Cox model analysis of 3680 cases of intraocular melanoma shows a decline in the prognostic value of size and cell type over time after tumor excision / Cancer 61 : 574 ~ 579
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