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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.10
- 수록면
- 267 - 272 (6page)
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Purpose: Hepatic resection and liver transplantation are surgical therapeutic options for small-sized HCC. But, the therapeutic option for patients meeting the Milan criteria with preserved liver function is facing a dilemma. In this study, we examined the outcomes of surgical resection for HCC patients meeting the Milan criteria with preserved liver function and rationale of hepatic resection as the first treatment for HCC meeting the Milan Criteria.
Methods: Between 1991 and 2006, 248 patients with HCC underwent hepatectomy in 158 primary HCC patients meeting Milan criteria (Group M) and in 90 patients beyond Milan criteria (Group N). Median age was 54.5 years in group M and 52.4 years in group N.
Results: The tumor size, mean survival months, E-S grade and vascular invasion rate were significantly different between the two groups. 67 patients in group M and 22 patients in group N had intrahepatic recurrence after primary hepatectomy. The cumulative 1, 3, and 5-year survival rates were 91.9%, 74.5%, and 60.5% in intrahepatic recurrence group M after primary hepatectomy and 100%, 96.0%, and 90.5% in repeated hepatic resection for recurrent treatment in group M, respectively.
Conclusion: Because of the high survival rate and long-term survival after adequate treatment of recurrence, primary hepatectomy is considered a reasonable option as first-line treatment for HCC meeting Milan criteria with preserved liver function.
Methods: Between 1991 and 2006, 248 patients with HCC underwent hepatectomy in 158 primary HCC patients meeting Milan criteria (Group M) and in 90 patients beyond Milan criteria (Group N). Median age was 54.5 years in group M and 52.4 years in group N.
Results: The tumor size, mean survival months, E-S grade and vascular invasion rate were significantly different between the two groups. 67 patients in group M and 22 patients in group N had intrahepatic recurrence after primary hepatectomy. The cumulative 1, 3, and 5-year survival rates were 91.9%, 74.5%, and 60.5% in intrahepatic recurrence group M after primary hepatectomy and 100%, 96.0%, and 90.5% in repeated hepatic resection for recurrent treatment in group M, respectively.
Conclusion: Because of the high survival rate and long-term survival after adequate treatment of recurrence, primary hepatectomy is considered a reasonable option as first-line treatment for HCC meeting Milan criteria with preserved liver function.
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REFERENCES
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Mazzaferro V / 1996 / Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis / N Engl J Med 334 : 693 ~ 699
2. [학술지(정기간행물)] - Adam R / 2003 / Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: a reasonable strategy? / Ann Surg 238 : 508 ~ 519
3. [학술지(정기간행물)] - Belghiti J / 2003 / Resection prior to liver transplantation for hepatocellular carcinoma / Ann Surg 238 : 885 ~ 893
4. [학술지(정기간행물)] - Figueras J / 2000 / Resection or transplantation for hepatocellular carcinoma in cirrhotic patients: outcomes based on indicated treatment strategy / J Am Coll Surg 190 : 580 ~ 587
5. [학술지(정기간행물)] - Sarasin FP / 1998 / Partial hepatectomy or orthotopic liver transplantation for the treatment of resectable hepatocellular carcinoma? A cost-effectiveness perspective / Hepatology 28 : 436 ~ 442
2. [학술지(정기간행물)] - Adam R / 2003 / Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: a reasonable strategy? / Ann Surg 238 : 508 ~ 519
3. [학술지(정기간행물)] - Belghiti J / 2003 / Resection prior to liver transplantation for hepatocellular carcinoma / Ann Surg 238 : 885 ~ 893
4. [학술지(정기간행물)] - Figueras J / 2000 / Resection or transplantation for hepatocellular carcinoma in cirrhotic patients: outcomes based on indicated treatment strategy / J Am Coll Surg 190 : 580 ~ 587
5. [학술지(정기간행물)] - Sarasin FP / 1998 / Partial hepatectomy or orthotopic liver transplantation for the treatment of resectable hepatocellular carcinoma? A cost-effectiveness perspective / Hepatology 28 : 436 ~ 442
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UCI(KEPA) : I410-ECN-0101-2013-514-002650557