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논문 기본 정보

자료유형
학술저널
저자정보
박승연 (가천의과대학교 길병원) 박흥규 (가천대학교 길병원)
저널정보
대한종양외과학회 KOREAN JOURNAL OF CLINICAL ONCOLOGY Korean Journal of Clinical Oncology 제6권 제2호
발행연도
2010.12
수록면
52 - 56 (5page)

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Background: Due to the increment of general interest in breast cancer and the early screening examination, the rate of early breast cancer is relatively increasing, along the rate of the successful treatment. Even at the earlier stage of breast cancer, the process of axillary lymph node metastasis is significant for treatment and prognosis of the cancer. Therefore, the aim of the study is to identify the factors that influence the lymph node metastasis among the patients with T1 breast cancer.
Methods: Between January 2003 and May 2008, 204 patients diagnosed as infiltrating ductal carcinoma after the breast cancer resection at Gachon University Gil Hospital were enrolled in the study. Each patient"s age, size and location of cancer, number of tumor, tissue and nuclear grade, infiltration of lymph vessels, immunohistochemistry test result(ER, PR, p53, HER2, Ki67, etc.), and axillary lymph node status were compared. Results: 10 out of 204 patients had cancer smaller than 0.5cm(T1a), 22 patients had cancer size larger than 0.5cm and smaller than 1cm(T1b), and 172 patients had cancer size larger than 1cm(T1c). For the rate of axillary lymph node metastasis, in the group of T1a, 1/10(10%) patients showed axillary lymph node metastasis, in T1b, 2/22(9.1%) patients showed axillary lymph node metastasis and in T1c, 54/172(31.3%) patients showed axillary lymph node metastasis. The result distinguished by the size of the cancer was statistically significant(p=0.039). The number of tumor was sorted as 1, 2, and more than 3, and each integer was 179, 17, and 8 patients. The rate of axillary lymph node metastasis according to the number of tumor was 48/179(26.8%) with 1 tumor, 5/17(29.4%) with 2 tumors, and 4/8(50%) with more than 3 tumors. This result distinguished by the number of tumor was also statistically significant(p=0007). Also, Lymphovascular invasion was statistically significant(p=0001). The rate of axillary lymph node metastasis did not show the statistical significance with the age of patients, location of cancer, tissue and nuclear grade, and immunohistochemistochemical staining result.
Conclusion: It Is considered that the size and the number of tumor, and lymphovascular infiltration are the significant factors influencing axillary lymph node metastasis of the T1 invasive ductal carcinoma. Furthermore, it is expected that the size and the number of tumor in preoperative ultasonography will be helpful determining the axillary lymph node dissection.

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UCI(KEPA) : I410-ECN-0101-2014-513-001300180