지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 57 - 63 (7page)
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초록· 키워드
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Purpose: <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography(<sup>18</sup>F-FDG PET/CT) has been recommended as a diagnostic modality for preoperative staging of breast cancer. But, the information for FDG uptake on axillary lymph node(ALN) is not sufficient. Authors investigated the FDG uptake on ALN in preoperative <sup>18</sup>F-FDG PET/CT and tumor characteristics to figure out association and its clinical significance. Materials and Methods: From Jan. to Dec. 2007, 176 patients had been performed preoperative <sup>18</sup>F-FDG PET/CT. Only sixty-five cases were confirmed as ALN metastasis in pathologic report. Thirty-one patients with high FDG uptake of ALN (SUVmax>1.0) and thirty-four with low FDG uptake (SUVmax≤1.0) in <sup>18</sup>F-FDG PET/CT were classified as group A and B, respectively. Results: The FDG uptake of ALN showed significant relationship with poor prognostic factors of primary tumor(worse histologic grade, negativity of estrogen and progesterone receptor, positivity of p53 and c-erbB2 gene, tumor necrosis, lymphovascular invasion) and ALN metastasis. In multivariate analysis, FDG uptake of ALN showed larger tumor size(p=0.001), higher Ki-67 (p=0.004), bigger and more metastatic ALN(p=0.017, <0.001)compared to low FDG uptake of ALN. The cut-off values of high FDG uptake were 1.85cm of primary tumor size, 17.5% of Ki-67, 2.5 and 0.95cm of number and size of metastatic ALN. Conclusion: The most valuable sensitivity and specificity of FDG uptake in metastatic ALN were shown when the number and size of ALN was more than 3 or 0.95cm and they would be large enough to perform ultrasonography-guided biopsy. We recommend preoperative ALN biopsy for the cases of FDG uptake on ALN in preoperative <sup>18</sup>F-FDG PET/CT and the sentinel lymph node biopsy might be skipped if metastasis is confirmed on biopsy.
목차
Introduction
Materials and Methods
Results
Discussion
Conclusion
REFERENCES
Abstract
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UCI(KEPA) : I410-ECN-0101-2014-513-001300195