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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 20 - 24 (5page)
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초록· 키워드
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Cancer Stem Cells
Recent results have supported the cancer stem cells hypothesis in which tumors originate from tissue stem cells or their early progenitors and, as a result, produce tumors that retain stem cell properties. These properties drive tumorigenesis and differentiation that contributes to cellular heterogeneity. In breast cancers, a cell population of surface marker CD44<sup>+</sup>CD24<sup>-or low</sup> is highly tumorigenic. Aldehyde dehydronase(ALDH) positive cells are also powerfully tumorigenic and this marker can be poor prognostic factor in breast cancer patients. The number of cancer stem cells is very small, and is tightly controlled by the self-renewal pathway and the signals of their environment (niche). Epithelial-mesenchymal transition(EMT) is a key development program that is often activated during cancer invasion and metastasis. Although our understanding of the biology of these cancer stem cells remains rudimentary, the existence of these cells has implications for current conceptualization of malignant transformation and the treatment of cancer.
Recent results have supported the cancer stem cells hypothesis in which tumors originate from tissue stem cells or their early progenitors and, as a result, produce tumors that retain stem cell properties. These properties drive tumorigenesis and differentiation that contributes to cellular heterogeneity. In breast cancers, a cell population of surface marker CD44<sup>+</sup>CD24<sup>-or low</sup> is highly tumorigenic. Aldehyde dehydronase(ALDH) positive cells are also powerfully tumorigenic and this marker can be poor prognostic factor in breast cancer patients. The number of cancer stem cells is very small, and is tightly controlled by the self-renewal pathway and the signals of their environment (niche). Epithelial-mesenchymal transition(EMT) is a key development program that is often activated during cancer invasion and metastasis. Although our understanding of the biology of these cancer stem cells remains rudimentary, the existence of these cells has implications for current conceptualization of malignant transformation and the treatment of cancer.
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UCI(KEPA) : I410-ECN-0101-2014-513-001300408