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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.9
- 수록면
- 180 - 185 (6page)
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Purpose: The purpose of this study was to evaluate the effect of combination intraluminal brachytherapy (ILBT) and external beam radiotherapy (EBRT) on patient survival and stent patency after metallic biliary stent placement in patients with unresectable hilar cholangiocarcinoma.
Methods: We retrospectively analyzed the data of 29 patients with unresectable hilar cholangiocarcinoma who presented between January 2002 and December 2006. Fifteen patients were treated with metallic stents alone (RT (-) group), and 14 patients were treated with ILBT and EBRT after metallic stent placement (RT (+) group). ILBT was performed using a 192Ir source at a dose of 15 Gy in 3 fractions. The EBRT dose was 45 Gy in 25 fractions.
Results: The 1- and 3-year patient survival rates in the RT (+) group were 51.9% and 8.7%, respectively, and those in the RT (-) group were 46.7% and 38.9%, respectively. However, there was no statistically significant difference in the survival rates between the two groups (p=0.38). The 1- and 2-year stent patency rates for the RT (+) group were numerically higher than those in the RT (-) group (74.0%, 74.0%, respectively vs. 59.9%, 39.9%, respectively), but not to a statistically significant degree (p=0.11). The median stent patency was 10 months in the RT (+) group and 8 months in the RT (-) group. All of the stents obstructed at 31 months in the RT (+) group and at 26 months in the RT (-) group. Four patients showed minor complications, including gastrointestinal discomfort and dermatitis after radiation therapy, but all of them responded well to conservative treatment.
Conclusion: Although combined ILBT and EBRT for unresectable hilar cholangiocarcinoma was safely carried out after biliary stent insertion with minor complications, it did not have a significant role in improving the survival and stent patency rates.
Methods: We retrospectively analyzed the data of 29 patients with unresectable hilar cholangiocarcinoma who presented between January 2002 and December 2006. Fifteen patients were treated with metallic stents alone (RT (-) group), and 14 patients were treated with ILBT and EBRT after metallic stent placement (RT (+) group). ILBT was performed using a 192Ir source at a dose of 15 Gy in 3 fractions. The EBRT dose was 45 Gy in 25 fractions.
Results: The 1- and 3-year patient survival rates in the RT (+) group were 51.9% and 8.7%, respectively, and those in the RT (-) group were 46.7% and 38.9%, respectively. However, there was no statistically significant difference in the survival rates between the two groups (p=0.38). The 1- and 2-year stent patency rates for the RT (+) group were numerically higher than those in the RT (-) group (74.0%, 74.0%, respectively vs. 59.9%, 39.9%, respectively), but not to a statistically significant degree (p=0.11). The median stent patency was 10 months in the RT (+) group and 8 months in the RT (-) group. All of the stents obstructed at 31 months in the RT (+) group and at 26 months in the RT (-) group. Four patients showed minor complications, including gastrointestinal discomfort and dermatitis after radiation therapy, but all of them responded well to conservative treatment.
Conclusion: Although combined ILBT and EBRT for unresectable hilar cholangiocarcinoma was safely carried out after biliary stent insertion with minor complications, it did not have a significant role in improving the survival and stent patency rates.
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방법
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고찰
참고문헌
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Klatskin G / 1965 / Adenocarcinoma of the hepatic duct at its bifurcation within the porta hepatic. An unusual tumor with distinctive clinical and pathological features / Am J Med 38 : 241 ~ 256
2. [학술지(정기간행물)] - Kahn AZ / 2007 / Trends in the surgical management of Klatskin tumors / Br J Surg 94 : 393 ~ 394
3. [학술지(정기간행물)] - Bismuth H / 1988 / Resection or palliation: priority of surgery in the treatment of hilar cancer / World J Surg 12 : 39 ~ 47
4. [학술지(정기간행물)] - Rumalla A / 1999 / Evaluation and endoscopic palliation of cholangiocarcinoma / Dig Dis 17 : 194 ~ 200
5. [학술지(정기간행물)] - Gonzalez Gonzalez D / 1990 / Results of radiation therapy in carcinoma of the proximal bile duct (Klatskin tumor) / Semin Liver Dis 10 : 131 ~ 141
2. [학술지(정기간행물)] - Kahn AZ / 2007 / Trends in the surgical management of Klatskin tumors / Br J Surg 94 : 393 ~ 394
3. [학술지(정기간행물)] - Bismuth H / 1988 / Resection or palliation: priority of surgery in the treatment of hilar cancer / World J Surg 12 : 39 ~ 47
4. [학술지(정기간행물)] - Rumalla A / 1999 / Evaluation and endoscopic palliation of cholangiocarcinoma / Dig Dis 17 : 194 ~ 200
5. [학술지(정기간행물)] - Gonzalez Gonzalez D / 1990 / Results of radiation therapy in carcinoma of the proximal bile duct (Klatskin tumor) / Semin Liver Dis 10 : 131 ~ 141
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UCI(KEPA) : I410-ECN-0101-2014-514-001254402