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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.9
- 수록면
- 165 - 172 (8page)
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Purpose: Surgery remains the only curative option for patients with extrahepatic bile duct cancer (EHBD Ca). But, long-term survival is typically not good because of the advanced stage of disease at the time of diagnosis and frequent disease recurrence after surgical resection. The purpose of this study was to evaluate factors that influence survival and recurrence after surgical resection of EHBD Ca.
Methods: A retrospective analysis of 113 patients who had received surgical resection for EHBD Ca between 2004 and 2009 was done. We investigated histopathological features, and survival and recurrence rates, and evaluated prognostic factors affecting survival and disease recurrence after surgical resection.
Results: Overall survival rates for 1, 3 and 5 years were 73.2%, 42.8%, and 36.0% respectively. In univariate analysis, prognostic factors influencing survival were histologic differentiation, T stage, lymph node (LN) metastasis, TNM stage, perineural invasion (PNI), lymphovascular invasion (LVI) and resection margin state. Among them, LN metastasis, PNI and resection margin state were found to be independent prognostic factors for overall survival in multivariate analysis. Recurrence occurred in 44 patients (48.9%) and disease-free survival rates were 50.6% at 1 year and 38.3% at 3 year. Univariate analysis revealed that histologic differentiation, T stage, LN metastasis, TNM stage, PNI and LVI were significantly associated with recurrence. In multivariate analysis, only LN metastasis was found to be a significant independent predictor of recurrence.
Conclusion: LN metastasis, PNI and positive resection margin were significant prognostic factors affecting survival. LN metastasis was found to be a significant independent predictor of recurrence in surgical resection of EHBD Ca.
Methods: A retrospective analysis of 113 patients who had received surgical resection for EHBD Ca between 2004 and 2009 was done. We investigated histopathological features, and survival and recurrence rates, and evaluated prognostic factors affecting survival and disease recurrence after surgical resection.
Results: Overall survival rates for 1, 3 and 5 years were 73.2%, 42.8%, and 36.0% respectively. In univariate analysis, prognostic factors influencing survival were histologic differentiation, T stage, lymph node (LN) metastasis, TNM stage, perineural invasion (PNI), lymphovascular invasion (LVI) and resection margin state. Among them, LN metastasis, PNI and resection margin state were found to be independent prognostic factors for overall survival in multivariate analysis. Recurrence occurred in 44 patients (48.9%) and disease-free survival rates were 50.6% at 1 year and 38.3% at 3 year. Univariate analysis revealed that histologic differentiation, T stage, LN metastasis, TNM stage, PNI and LVI were significantly associated with recurrence. In multivariate analysis, only LN metastasis was found to be a significant independent predictor of recurrence.
Conclusion: LN metastasis, PNI and positive resection margin were significant prognostic factors affecting survival. LN metastasis was found to be a significant independent predictor of recurrence in surgical resection of EHBD Ca.
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참고문헌
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Carriaga MT / 1995 / Liver, gallbladder, extrahepatic bile ducts, and pancreas / Cancer 75 (Suppl 1) : 171 ~ 190
2. [학술지(정기간행물)] - Hai-Rim Shin / 2004 / 2002 Annual Report of the Korea Central Cancer Registry: Based on Registered Data from 139 Hospitals / Cancer Research and Treatment 36 (2) : 103 ~ 114
3. [학술지(정기간행물)] - Longmire WP / 1973 / Carcinoma of the extrahepatic biliary tract / Ann Surg 178 : 333 ~ 345
4. [학술지(정기간행물)] - Nagorney DM / 1993 / Outcomes after curative resections of cholangiocarcinoma / Arch Surg 128 : 871 ~ 877
5. [학술지(정기간행물)] - Park SW / 2004 / Patterns and relevant factors of tumor recurrence for extrahepatic bile duct carcinoma after radical resection / Hepatogastroenterology 51 : 1612 ~ 1618
2. [학술지(정기간행물)] - Hai-Rim Shin / 2004 / 2002 Annual Report of the Korea Central Cancer Registry: Based on Registered Data from 139 Hospitals / Cancer Research and Treatment 36 (2) : 103 ~ 114
3. [학술지(정기간행물)] - Longmire WP / 1973 / Carcinoma of the extrahepatic biliary tract / Ann Surg 178 : 333 ~ 345
4. [학술지(정기간행물)] - Nagorney DM / 1993 / Outcomes after curative resections of cholangiocarcinoma / Arch Surg 128 : 871 ~ 877
5. [학술지(정기간행물)] - Park SW / 2004 / Patterns and relevant factors of tumor recurrence for extrahepatic bile duct carcinoma after radical resection / Hepatogastroenterology 51 : 1612 ~ 1618
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UCI(KEPA) : I410-ECN-0101-2014-514-001000279