지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: We performed this study to compare the antidiabetic effects of Coptidis Rhizoma (CR) and its major component berberine with gliclazide.
Materials and Methods: Diabetic rats induced by injection of streptozotocin (STZ) 55mg/kg were treated with CR 100, 200, 400mg/kg and berberine 100mg/kg. After rats were treated for 5 days, serum glucose, total cholesterol, triglyceride, BUN, creatinine and antioxidant levels were determined.
Results: The cytotoxic effects of CR (0.1, 0.01, and 0.001mg/mL), berberine and gliclazide (0.1μM, 1μM, and 10μM) were tested in rat insulinoma (RIN) cells induced with 5mM STZ. The levels of fasting blood glucose, total cholesterol, triglyceride, BUN and creatinine of CR and berberine treated groups were reduced as much as that of gliclazide group in comparison to control groups, whereas total antioxidant levels increased. In vitro experiments showed that CR and berberine have a cytoprotective effect on RIN cells.
Materials and Methods: Diabetic rats induced by injection of streptozotocin (STZ) 55mg/kg were treated with CR 100, 200, 400mg/kg and berberine 100mg/kg. After rats were treated for 5 days, serum glucose, total cholesterol, triglyceride, BUN, creatinine and antioxidant levels were determined.
Results: The cytotoxic effects of CR (0.1, 0.01, and 0.001mg/mL), berberine and gliclazide (0.1μM, 1μM, and 10μM) were tested in rat insulinoma (RIN) cells induced with 5mM STZ. The levels of fasting blood glucose, total cholesterol, triglyceride, BUN and creatinine of CR and berberine treated groups were reduced as much as that of gliclazide group in comparison to control groups, whereas total antioxidant levels increased. In vitro experiments showed that CR and berberine have a cytoprotective effect on RIN cells.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - Li WL / 2004 / Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus / J Ethnopharmacol 92 (1) : 1 ~ 21
2. [학술지(정기간행물)] - Cockram CS / 2000 / Diabetes mellitus: perspective from the Asia-Pacific region / Diabetes Res Clin Pract 50 (2) : S3 ~ S7
3. [단행본] - Heo J / 1999 / Dongeuibogam / Bubin publisher co : 1341 ~
4. [학술지(정기간행물)] - Choi YS / 1996 / Effects of extracts of Coptis japonica on lipid metabolism in rats / Kor J Pharmacogn 27 (3) : 246 ~ 253
5. [학술지(정기간행물)] - Kim YJ / 2000 / Antioxidant activity of water-extract from Coptidis chinensis Franch / Journal of Life Science 10 (3) : 241 ~ 246
2. [학술지(정기간행물)] - Cockram CS / 2000 / Diabetes mellitus: perspective from the Asia-Pacific region / Diabetes Res Clin Pract 50 (2) : S3 ~ S7
3. [단행본] - Heo J / 1999 / Dongeuibogam / Bubin publisher co : 1341 ~
4. [학술지(정기간행물)] - Choi YS / 1996 / Effects of extracts of Coptis japonica on lipid metabolism in rats / Kor J Pharmacogn 27 (3) : 246 ~ 253
5. [학술지(정기간행물)] - Kim YJ / 2000 / Antioxidant activity of water-extract from Coptidis chinensis Franch / Journal of Life Science 10 (3) : 241 ~ 246
이 논문의 저자 정보
이 논문과 함께 이용한 논문
The inhibition of inflammatory molecule expression on 3T3-L1 adipocytes by berberine is not mediated by leptin signaling
Bong-Hyuk Choi
,
Yu-Hee Kim
,
In-Sook Ahn
외 3명
Nutrition Research and Practice
2009
.06
Berberine Inhibited Radioresistant Effects and Enhanced Anti-Tumor Effects in the Irradiated-Human Prostate Cancer Cells
Jung-Mu Hu
,
Dongho Kim
Toxicological Research
2010
.06
Berberine Chloride Inhibits Receptor Activator of NF-κB Ligand-induced Osteoclastogenesis via Preventing ERK Activation
Myeong Sook Cheon
,
Myung Hee Kim
,
Su-Ui Lee
외 4명
한국한의학연구원 논문집
2007
.08
Anti-obesity Effect of Berberine in Mice Fed a High Fat Diet
Kwang-Hyun Hwang
,
Ji-Yun Ahn
,
Suna Kim
외 1명
Journal of Food Science and Nutrition
2009
.12
마우스 림프구증식과 GM-CSF생성에 미치는 Berberine의 효과
김은영
,
노민희
,
정양숙
외 2명
생명과학회지
2007
.05
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-519-000273044