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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.6
- 수록면
- 109 - 115 (7page)
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The purpose of this study was to elucidate the mechanism underlying enhanced radiosensitivity to ??Co γ-irradiation in human prostate PC-3 cells pretreated with berberine. The cytotoxic effect of the combination of berberine and irradiation was superior to that of berberine or irradiation alone. Cell death and Apoptosis increased significantly with the combination of berberine and irradiation. Additionally, ROS generation was elevated by berberine with or without irradiation. The antioxidant NAC inhibited berberine andradiation-induced cell death. Bax, caspase-3, p53, p38, and JNK activation increased, but activation of Bcl-2, ERK, and HO-1 decreased with berberine treatment with or without irradiation. Berberine inhibited the anti-apoptotic signal pathway involving the activation of the HO-1/NF-κB-mediated survival pathway, which prevents radiation-induced cell death. Our data demonstrate that berberine inhibited the radioresistant effects and enhanced the radiosensitivity effects in human prostate cancer cells via the MAPK/ caspase-3 and ROS pathways.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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Genomic Screening for Targets Regulated by Berberine in Breast Cancer Cells
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Antioxidant Effect of Berberine and its Phenolic Derivatives Against Human Fibrosarcoma Cells
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Influence of berberine on the blood pressure of rabbits
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Berberine inhibits interleukin-5-induced Stat5 activation for proliferation and survival of pro-B Y16 cells
한국응용약물학회 춘계학술발표논문집
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황련(黃連)의 주성분인 Berberine의 뇌신경소교세포로부터 LPS에 의해 유도되는 염증매개물질 생성억제효과
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Enhancement of Arsenic Trioxide ($As_2O_3$)-Mediated Apoptosis Using Berberine in Human Neuroblastoma SH-SY5Y Cells
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[Free Paper] Effect of Berberine on p53 Expression by TPA in Breast Cancer Cells
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Berberine이 백서의 6-Hydroxydopamine-유도 파킨슨병 모델에서의 L-DOPA 요법에 미치는 영향
약학회지
2011 .01
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Transport mechanism of berberine across Caco-2 cell monolayers
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Discovery and characterization of berberine derivatives as stimulators of osteoblast differentiation
International Journal of Oral Biology
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Berberine Chloride Inhibits Receptor Activator of NF-κB Ligand-induced Osteoclastogenesis via Preventing ERK Activation
한국한의학연구원 논문집
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Therapeutic Effects of Coptidis Rhizoma and Berberine in Streptozotocin-induced Diabetic Rats
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2011 .11
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UCI(KEPA) : I410-ECN-0101-2010-513-002878576