지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.6
- 수록면
- 84 - 88 (5page)
이용수
초록· 키워드
오류제보하기
In our previous study, we have shown that berberine has both anti-adipogenic and anti-inflammatory effects on 3T3-L1 adipocytes, and the anti-adipogenic effect is due to the down-regulation of adipogenic enzymes and transcription factors. Here we focused more on anti-inflammatory effect of berberine using real time RT-PCR and found it changes expressions of adipokines. We hypothesized that anti-adipogenicity of berberine mediates anti-inflammtory effect and explored leptin as a candidate mediator of this signaling. We studied this hypothesis by western blot analysis, but our results showed that berberine has no effect on the phosphorylations of STAT-3 and ERK which have important roles on leptin signaling. These results led us to conclude that the anti-inflammatory effect of berberine is not mediated by the inhibition of leptin signal transduction. Moreover, we have found that berberine down-regulates NF-κB signaling, one of the inflammation-related signaling pathway, through western blot analysis. Taken together, the anti-inflammatory effect of berberine is not mediated by leptin, and berberine induces anti-inflammatory effect independent of leptin signaling.
목차
Abstract
Introduction
Materials and Methods
Results
Discussion
Literature cited
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The inhibition of inflammatory molecule expression on 3T3-L1 adipocytes by berberine is not mediated by leptin signaling
Nutrition Research and Practice
2009 .06
-
Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte
Experimental and Molecular Medicine
2006 .01
-
Anti - Helicobacter pylori Activity of the Berberine Analogs
한국생명과학회 심포지움
2002 .09
-
Neuroprotective Effects of Berberine in Neurodegeneration Model Rats Induced by Ibotenic Acid
Animal cells and systems
2008 .01
-
한약재 추출물의 피부 염증 유발 세균에 대한 항균활성
생명과학회지
2010 .07
-
마우스 림프구증식과 GM-CSF생성에 미치는 Berberine의 효과
생명과학회지
2007 .05
-
Berberine Induces p53-Dependent Apoptosis through Inhibition of DNA Methyltransferase3b in Hep3B Cells
대한임상검사과학회지
2020 .01
-
A sensitive and rapid LC-MS method for determination of berberine in human plasma
한국분석과학회 학술대회
2019 .05
-
Fractionated Coptis chinensis Extract and Its Bioactive Component Suppress Propionibacterium acnes-Stimulated Inflammation in Human Keratinocytes
Journal of Microbiology and Biotechnology
2018 .01
-
베르베린이 마우스 전염증성 사이토카인의 생성에 미치는 영향
생명과학회지
2010 .08
-
The Antifungal Mode of Action of a 13-(4-isopropylbenzyl)berberine Derivative, KR-72
한국미생물학회 학술대회논문집
2014 .04
-
[화학] 황련 중 berberine의 추출효율에 관한 연구
분석과학
1997 .04
-
Leptin: A Multifunctional Role as an Immunomodulator in Mycobacterial Lung Disease
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2013 .03
-
Antifungal Activity of Chaerophylline and Berberine Hydroxide Isolated from Corydalis Species
Mycobiology
2001 .01
-
과천지역 초등학생의 Leptin 수준과 열량섭취, 체중 및 비만도 변화와의 관계
한국영양학회지
2007 .12
-
Increased Serum Leptin Levels and Leptin mRNA Gene Expression by Zinc Depletion in Rats
Nutritional Sciences
2002 .11
-
Effect of Dietary High fat on Serum Leptin Level and Adipocyte Mass in Male Rats
대한지역사회영양학회지
2001 .08
-
Potent Anti-influenza Effects of Novel mPGES-1 Inhibitors Mediated by Inhibition of PI3K/AKT Signaling Pathway and Pro-inflammatory Gene Expression
한국미생물학회 학술대회논문집
2015 .04
-
Targeted sampling plan & analysis of metoclopramide, berberine, DL-methylephedrine HCl and tildipirosin in cow
한국분석과학회 학술대회
2020 .06
-
Solvent effect on the UV/Vis absorption and fluorescence spectroscopic properties of berberine
Photochemical & photobiological sciences : an international journal
2009 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Berberine Inhibited Radioresistant Effects and Enhanced Anti-Tumor Effects in the Irradiated-Human Prostate Cancer Cells
Jung-Mu Hu
,
Dongho Kim
Toxicological Research
2010
.06
Therapeutic Effects of Coptidis Rhizoma and Berberine in Streptozotocin-induced Diabetic Rats
Kee-Tae Kweon
,
Sang-young Ahn
,
In-hye Ham
외 2명
대한한의학회지
2011
.11
Anti-obesity Effect of Berberine in Mice Fed a High Fat Diet
Kwang-Hyun Hwang
,
Ji-Yun Ahn
,
Suna Kim
외 1명
Journal of Food Science and Nutrition
2009
.12
Berberine Chloride Inhibits Receptor Activator of NF-κB Ligand-induced Osteoclastogenesis via Preventing ERK Activation
Myeong Sook Cheon
,
Myung Hee Kim
,
Su-Ui Lee
외 4명
한국한의학연구원 논문집
2007
.08
동과 분획물이 3T3-L1 지방세포 분화 억제에 미치는 영향
유양희
,
전우진
한국식품영양과학회지
2012
.07
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2012-594-004464420