지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objective: Increased aortic and carotid arterial augmentation index (AI) is associated with the risk of cardiovascular disease. The most widely used approach for determining central arterial AI is by calculating the aortic pressure waveform from radial arterial waveforms using a transfer function. But how the change of waveform by applied pressure and the pattern of the change rely on subject’s characteristics has not been recognized. In this study, we use a new method for measuring radial waveform and observe the change of waveform and the deviation of radial AI in the same position by applied pressure.
Method: Forty-six non-patient volunteers (31 men and 15 women, age range 21-58 years) were enrolled for this study. Informed consent in a form approved by the institutional review board was obtained in all subjects. Blood pressure was measured on the left upper arm using an oscillometric method, radial pressure waves were recorded with the use of an improved automated tonometry device. DMP-3000(DAEYOMEDI Co., Ltd. Ansan, Korea) has robotics mechanism to scan and trace automatically. For each subject, we performed the procedure 5 times for each applied pressure level. We could thus obtain 5 different radial pulse waveforms for the same person’s same position at different applied pressures. All these processes were repeated twice for test reproducibility.
Result: Aortic AI, peripheral AI and radial AI were higher in women than in men (P<0.01), radial AI strongly correlated with aortic AI, and radial AI was consistently approximately 39% higher than aortic AI. Relationship between representative radial AI of DMP-3000 and peripheral AI of SphygmoCor had strongly correlation. And there were three patterns in change of pulse waveform.
Conclusion: In this study, it is revealed the new device was sufficient to measure how radial AI and radial waveform from the same person at the same time change under applied pressure and it had inverse-proportion to applied pressure.
Method: Forty-six non-patient volunteers (31 men and 15 women, age range 21-58 years) were enrolled for this study. Informed consent in a form approved by the institutional review board was obtained in all subjects. Blood pressure was measured on the left upper arm using an oscillometric method, radial pressure waves were recorded with the use of an improved automated tonometry device. DMP-3000(DAEYOMEDI Co., Ltd. Ansan, Korea) has robotics mechanism to scan and trace automatically. For each subject, we performed the procedure 5 times for each applied pressure level. We could thus obtain 5 different radial pulse waveforms for the same person’s same position at different applied pressures. All these processes were repeated twice for test reproducibility.
Result: Aortic AI, peripheral AI and radial AI were higher in women than in men (P<0.01), radial AI strongly correlated with aortic AI, and radial AI was consistently approximately 39% higher than aortic AI. Relationship between representative radial AI of DMP-3000 and peripheral AI of SphygmoCor had strongly correlation. And there were three patterns in change of pulse waveform.
Conclusion: In this study, it is revealed the new device was sufficient to measure how radial AI and radial waveform from the same person at the same time change under applied pressure and it had inverse-proportion to applied pressure.
목차
Introduction
Methods
Conclusions
References
참고문헌 (14)
참고문헌 신청
1. [단행본] - Nichols WW / 1998 / McDonald’s Blood Flow in Arteries. in Theoretical, Experimental and Clinical Principles / Edward Arnold : 201 ~ 202
2. [학술지(정기간행물)] - Nürnberger J / 2002 / Augmentation index is associated with cardiovascular risk / J Hypertens 20 (12) : 2407 ~ 2414
3. [학술지(정기간행물)] - Weber T / 2004 / Arterial stiffness, wave reflections, and the risk of coronary artery disease / Circulation 109 (2) : 184 ~ 189
4. [학술지(정기간행물)] - London GM / 2001 / Arterial wave reflections and survival in end-stage renal failure / Hypertension 38 (3) : 434 ~ 438
5. [학술지(정기간행물)] - Weber T / 2005 / Increased arterial wave reflections predict severe cardiovascular events in patients undergoing percutaneous coronary interventions / Eur Heart J 26 (24) : 2657 ~ 2663
2. [학술지(정기간행물)] - Nürnberger J / 2002 / Augmentation index is associated with cardiovascular risk / J Hypertens 20 (12) : 2407 ~ 2414
3. [학술지(정기간행물)] - Weber T / 2004 / Arterial stiffness, wave reflections, and the risk of coronary artery disease / Circulation 109 (2) : 184 ~ 189
4. [학술지(정기간행물)] - London GM / 2001 / Arterial wave reflections and survival in end-stage renal failure / Hypertension 38 (3) : 434 ~ 438
5. [학술지(정기간행물)] - Weber T / 2005 / Increased arterial wave reflections predict severe cardiovascular events in patients undergoing percutaneous coronary interventions / Eur Heart J 26 (24) : 2657 ~ 2663
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UCI(KEPA) : I410-ECN-0101-2014-519-000263708