지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.2
- 수록면
- 120 - 131 (12page)
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Objective: The purpose of this study is to compare the surgical treatment with conservative treatment and to evaluate the effectiveness of drug holiday in bisphosphonate related osteonecrosis of the jaw (BRONJ) patients who were diagnosed as stage 2.
Patients and Method: From January 2012 to October 2014, seventy two patients who visit to Pusan National University of Dental Hospital were diagnosed as stage 2 of BRONJ. All the patients had taken computed tomography(CT) and panoramic radiography. The surgical treatment including sequestrectomy of necrotic bone and curettage of soft tissue around the sequestrum were performed to fifty patients. Twenty two patients underwent conservative treatment such as antibiotics medications, mouth rinsing and follow up checking for every two weeks. Prognosis of treatment was classified into 3 groups ? response, unresponse, and worsens according to clinical, radiographic symptoms. P value less than 0.05 were regarded as significant.
Results: In surgery group, forty five patients (90%) were healed without recurrence or any complication and five patients (10%) showed the wound dehiscence or infection. In conservative treatment group, fifteen patients (68.2%) were healed without any complication, four patients (18.2%) did not show improvement and three(4.2%) patients°Ø symptoms increased. P value among groups was 0.014. Evaluation of preoperative drug holiday in surgery group did not show the effectiveness(p=0.478).
Conclusion: Statistically, the prognosis of patients with stage 2 BRONJ treated with surgery was significantly better than conservative treatment. There was no statistical difference for the preoperative drug holiday.
Patients and Method: From January 2012 to October 2014, seventy two patients who visit to Pusan National University of Dental Hospital were diagnosed as stage 2 of BRONJ. All the patients had taken computed tomography(CT) and panoramic radiography. The surgical treatment including sequestrectomy of necrotic bone and curettage of soft tissue around the sequestrum were performed to fifty patients. Twenty two patients underwent conservative treatment such as antibiotics medications, mouth rinsing and follow up checking for every two weeks. Prognosis of treatment was classified into 3 groups ? response, unresponse, and worsens according to clinical, radiographic symptoms. P value less than 0.05 were regarded as significant.
Results: In surgery group, forty five patients (90%) were healed without recurrence or any complication and five patients (10%) showed the wound dehiscence or infection. In conservative treatment group, fifteen patients (68.2%) were healed without any complication, four patients (18.2%) did not show improvement and three(4.2%) patients°Ø symptoms increased. P value among groups was 0.014. Evaluation of preoperative drug holiday in surgery group did not show the effectiveness(p=0.478).
Conclusion: Statistically, the prognosis of patients with stage 2 BRONJ treated with surgery was significantly better than conservative treatment. There was no statistical difference for the preoperative drug holiday.
목차
ABSTRACT
Ⅰ. 서론
Ⅱ. 연구 대상 및 방법
Ⅲ. 연구 결과
Ⅳ. 총괄 및 고찰
Ⅴ. 결론
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UCI(KEPA) : I410-ECN-0101-2016-515-001070254