지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 193 - 204 (12page)
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초록· 키워드
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Objectives: This study examined the statistical relevance of whether the systemic predisposing factors affect the prognosis of surgical treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ). All cases had undergone bone biopsies to determine the characteristics of the mechanisms of BRONJ by optical microscopy.Materials and Methods: The data included 54 BRONJ cases who underwent surgery and in whom bone biopsies were performed. The results of surgery were evaluated and the results were classified into 3 categories: normal recovery, delayed recovery, and recurrence after surgery. The medical history, such as diabetes mellitus, medication of steroids, malignancies on other sites was investigated for an evaluation of the systemic predispos-ing factors in relation to the prognosis. The three factors involved with the medication of bisphosphonate (BP) were the medication route, medication period, and drug holiday of BP before surgery. The serum C-terminal cross-linking telopeptide (CTX) value and presence of microorganism colony in bone biopsy specimens were also checked. Statistical analysis was then carried out to determine the relationship between these factors and the results of surgery.Results: The group of patients suffering from diabetes and on steroids tended to show poorer results after surgery. Parenteral medication of BP made the patients have a poorer prognosis after surgery than oral medication. In contrast, the medication period and drug holiday of BP before surgery did not have significance with the results of surgery nor did the serum CTX value and presence of microorganism colony. Necrotic bone specimens in this study typically showed disappearing new bone formation around the osteocytic lacunae and destroyed Howship’s lacunae.Conclusion: Although many variables exist, this study could in part, predict the prognosis of surgical treatment of BRONJ by taking the patient’s medical history.
목차
등록된 정보가 없습니다.
참고문헌 (45)
참고문헌 신청
McClung MR / 2003 / Bisphosphonates / Endocrinol Metab Clin North Am 32:253~271
Stanton DC / 2009 / Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 surgical cases / J Oral Maxillofac Surg 67:943~950
Marx RE / 2003 / Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic / J Oral Maxillofac Surg 61:1115~1117
Ruggiero SL / 2004 / Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases / J Oral Maxillofac Surg 62:527~534
Hinson AM / 2014 / Is bisphosphonate-related osteonecrosis of the jaw an infection? A histological and microbiological ten-year summary / Int J Dent
Stanton DC / 2009 / Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 surgical cases / J Oral Maxillofac Surg 67:943~950
Marx RE / 2003 / Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic / J Oral Maxillofac Surg 61:1115~1117
Ruggiero SL / 2004 / Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases / J Oral Maxillofac Surg 62:527~534
Hinson AM / 2014 / Is bisphosphonate-related osteonecrosis of the jaw an infection? A histological and microbiological ten-year summary / Int J Dent
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