지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 16 - 22 (7page)
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Objectives: Bisphosphonate is the primary cause of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Bisphosphonates are eliminated from the human body by the kidneys. It is anticipated that bisphosphonate levels in the body will increase if the kidney is in a weak state or if there is sys-temic disease that affects kidney function. The aim of this study was to analyze the relevance of renal function in the severity of BRONJ.Materials and Methods: Ninety-three patients diagnosed with BRONJ in Pusan National University Dental Hospital from January 2012 to Decem-ber 2014 were included in this study. All patients underwent a clinical exam, radiographs, and serologic lab test, including urine analysis. The patient’s medical history was also taken, including the type of bisphosphonate drug, the duration of administration and drug holiday, route of administration, and other systemic diseases. In accordance with the guidelines of the 2009 position paper of American Association of Oral and Maxillofacial Surgeons, the BRONJ stage was divided into 4 groups, from stage 0 to 3, according to the severity of disease. IBM SPSS Statistics version 21.0 (IBM Co., USA) was used to perform regression analysis with a 0.05% significance level.Results: BRONJ stage and renal factor (estimated glomerular filtration rate) showed a moderate statistically significant correlation. In the group with higher BRONJ stage, the creatinine level was higher, but the increase was not statistically significant. Other factors showed no significant correlation with BRONJ stage. There was a high statistically significant correlation between BRONJ stage and ‘responder group’ and ‘non-responder group,’ but there was no significant difference with the ‘worsened group.’ In addition, the age of the patients was a relative factor with BRONJ stage.Conclusion: With older age and lower renal function, BRONJ is more severe, and there may be a decrease in patient response to treatment.
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참고문헌 (25)
참고문헌 신청
/ / Background document for meeting of Advisory Committee for Reproductive Health Drugs and Drug Safety and Risk Management Advisory Committee
/ / Wikipedia: Renal function
Berenson JR / 2002 / American Society of Clinical Oncology clinical practice guidelines: the role of bisphosphonates in multiple myeloma / J Clin Oncol 20 : 3719 ~ 3736
Bone HG / 2004 / Ten years' experience with alendronate for osteoporosis in postmenopausal women / N Engl J Med 350 : 1189 ~ 1199
Coleman RE / 2000 / Optimising treatment of bone metastases by Aredia(TM) and Zometa(TM) / Breast Cancer 7 : 361 ~ 369
/ / Wikipedia: Renal function
Berenson JR / 2002 / American Society of Clinical Oncology clinical practice guidelines: the role of bisphosphonates in multiple myeloma / J Clin Oncol 20 : 3719 ~ 3736
Bone HG / 2004 / Ten years' experience with alendronate for osteoporosis in postmenopausal women / N Engl J Med 350 : 1189 ~ 1199
Coleman RE / 2000 / Optimising treatment of bone metastases by Aredia(TM) and Zometa(TM) / Breast Cancer 7 : 361 ~ 369
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