지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.2
- 수록면
- 51 - 58 (8page)
이용수
초록· 키워드
오류제보하기
Toxocariasis is a soil-transmitted helminthozoonosis due to infection of humans by larvae of Toxocara canis. The disease could produce cognitive and behavioral disturbances especially in children. Meanwhile, in our modern era, the incidence of immunosuppression has been progressively increasing due to increased incidence of malignancy as well as increased use of immunosuppressive agents. The present study aimed at comparing some of the pathological and immunological alterations in the brain of normal and immunosuppressed mice experimentally infected with T. canis. Therefore, 180 Swiss albino mice were divided into 4 groups including normal (control) group, immunocompetent T. canis-infected group, immunosuppressed group (control), and immunosuppressed infected group. Infected mice were subjected to larval counts in the brain, and the brains from all mice were assessed for histopathological changes, astrogliosis, and IL-5 mRNA expression levels in brain tissues. The results showed that under immunosuppression, there were significant increase in brain larval counts, significant enhancement of reactive gliosis, and significant reduction in IL-5 mRNA expression. All these changes were maximal in the chronic stage of infection. In conclusion, the immunopathological alterations in the brains of infected animals were progressive over time, and were exaggerated under the effect of immunosuppression as did the intensity of cerebral infection.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Identification of Pasteurella canis in a Soft Tissue Infection Caused by a Dog Bite: The First Report in Korea
Annals of Laboratory Medicine
2016 .01
-
First Case of Canine Infection with Hepatozoon canis (Apicomplexa: Haemogregarinidae) in the Republic of Korea
Parasites, Hosts and Diseases
2017 .10
-
Draft Genome of Toxocara canis, a Pathogen Responsible for Visceral Larva Migrans
Parasites, Hosts and Diseases
2016 .12
-
Comparison of cytokine genes related with immune responses in canine macrophages using different culture models after infection with Brucella canis
예방수의학회지
2019 .01
-
Pathological, immunohistochemical, and bacteriological findings in dogs infected with Brucella canis
Korean Journal of Veterinary Research(대한수의학회지)
2020 .03
-
Detection and molecular characterization of Hepatozoon canis, Babesia vogeli, Ehrlichia canis, and Anaplasma platys in dogs from Metro Manila, Philippines
Korean Journal of Veterinary Research(대한수의학회지)
2017 .08
-
Virulence-associated Genome Sequences of Pasteurella canis and Unique Toxin Gene Prevalence of P. canis and Pasteurella multocida Isolated from Humans and Companion Animals
Annals of Laboratory Medicine
2023 .05
-
Toxocariasis: A Rare Cause of Multiple Cerebral Infarction
Infection and Chemotherapy
2015 .01
-
Altered brain connectivity associated with behavioral impairments in DNA topoisomerase IIIβ mutant mice
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Prevalence of intestinal parasites in animal hosts and potential implications to animal and human health in Edo, Nigeria
Journal of Veterinary Science
2023 .01
-
From Gut to Brain: Alteration in Inflammation Markers in the Brain of Dextran Sodium Sulfate-induced Colitis Model Mice
Clinical Psychopharmacology and Neuroscience
2018 .01
-
Transcriptome sequencing revealed the inhibitory mechanism of ketoconazole on clinical Microsporum canis
Journal of Veterinary Science
2021 .01
-
Pathological findings of the mixed infection with canine distemper virus and Streptococcus canis on farmed badger
한국가축위생학회지
2018 .01
-
Development of Efficient Brain Age Estimation Method Based on Regional Brain Volume From Structural Magnetic Resonance Imaging
PSYCHIATRY INVESTIGATION
2024 .01
-
Mouse models for brain disease preclinical study
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Toxocara canis Mimicking a Metastatic Omental Mass from Sigmoid Colon Cancer: A Case Report
Annals of Coloproctology
2018 .01
-
정신건강의학과 의사를 위한 뇌파의 기초
신경정신의학
2019 .01
-
Primary Age-Related Tauopathy: An Elderly Brain Pathology Frequently Encountered during Autopsy
Journal of Pathology and Translational Medicine
2019 .01
-
Proposal Guidelines for Standardized Operating Procedures of Brain Autopsy: Brain Bank in South Korea
Yonsei Medical Journal
2017 .01
-
Creation of mouse models and analysis methods for the investigation of brain disorders
한국실험동물학회 학술발표대회 논문집
2022 .07
이 논문의 저자 정보
이 논문과 함께 이용한 논문
송이버섯 추출액의 항균력 확인과 저염젓갈 생산에 적용 가능성
김진성
,
박재범
,
장승원
외 4명
KSBB Journal
2015
.10
MALDI-MS 기반 당단백질 당쇄의 정량분석 기술 개발 연구 동향
김경진
,
김윤우
,
황철환
외 3명
KSBB Journal
2015
.10
Involvement of PI3K/AKT and MAPK Pathways for TNF-α Production in SiHa Cervical Mucosal Epithelial Cells Infected with Trichomonas vaginalis
Jung-Bo Yang
,
Juan-Hua Quan
,
Ye-Eun Kim
외 6명
Parasites, Hosts and Diseases
2015
.08
LPS로 유도된 RAW264.7 Cell과 마우스모델에 대한 잘피 에탄올 추출물의 항염증 효과
김민지
,
배난영
,
김꽃봉우리
외 4명
KSBB Journal
2015
.08
Production of Liquiritigenin with Cell-based Biotransformation and Its Anti-Aging Activity
Hye Jin Hwang
,
Sang Chul Jeong
,
Jong Pil Pa
외 1명
KSBB Journal
2015
.08
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-513-001133914