지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.88 No.4
- 발행연도
- 2015.3
- 수록면
- 200 - 207 (8page)
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초록· 키워드
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Purpose: This study aimed to evaluate the clinical significance of Ki-67 and p53 expressions in patients with pancreatic head cancer.
Methods: Between May 2008 and April 2013, immunohistochemical staining for Ki-67 and p53 was performed in 34 patients with pancreatic head cancer (ductal adenocarcinoma). All 34 patients underwent pancreaticoduodenectomy at Chonnam National University Hwasun Hospital, Hwasun, Korea. Clinical and histopathological characteristics were analyzed, relative to p53 expression.
Results: Thirty (88.2%) and twenty-one (61.7%) of the 34 pancreatic head cancers exhibited positive expression of Ki-67 and p53, respectively. Patients expressing Ki-67 and p53 experienced more frequent tumor recurrences within 1 year after surgical resection (P = 0.003 and P = 0.030, respectively). However, no correlation was detected between Ki-67 and p53 expression. Ki-67 expression was correlated with pathological grade, lymph node metasatsis, and clinical stage (P < 0.05). Importantly, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year in both univariable and multivariable analyses (odds ratio, 27.219; 95% confidence interval, 1.403?528.135; P = 0.029).
Conclusion: The expression of Ki-67 and p53 are significantly related to early postoperative recurrence within 1 year after surgical resection in pancreatic head cancer. Especially, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year. Therefore, immunohistochemical staining for Ki-67 and p53 may be applied as a predictive marker for early postoperative recurrence in pancreatic head cancer.
Methods: Between May 2008 and April 2013, immunohistochemical staining for Ki-67 and p53 was performed in 34 patients with pancreatic head cancer (ductal adenocarcinoma). All 34 patients underwent pancreaticoduodenectomy at Chonnam National University Hwasun Hospital, Hwasun, Korea. Clinical and histopathological characteristics were analyzed, relative to p53 expression.
Results: Thirty (88.2%) and twenty-one (61.7%) of the 34 pancreatic head cancers exhibited positive expression of Ki-67 and p53, respectively. Patients expressing Ki-67 and p53 experienced more frequent tumor recurrences within 1 year after surgical resection (P = 0.003 and P = 0.030, respectively). However, no correlation was detected between Ki-67 and p53 expression. Ki-67 expression was correlated with pathological grade, lymph node metasatsis, and clinical stage (P < 0.05). Importantly, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year in both univariable and multivariable analyses (odds ratio, 27.219; 95% confidence interval, 1.403?528.135; P = 0.029).
Conclusion: The expression of Ki-67 and p53 are significantly related to early postoperative recurrence within 1 year after surgical resection in pancreatic head cancer. Especially, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year. Therefore, immunohistochemical staining for Ki-67 and p53 may be applied as a predictive marker for early postoperative recurrence in pancreatic head cancer.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (25)
참고문헌 신청
1. [학술지(정기간행물)] - Warshaw AL. / 1992 / Pancreatic carcinoma / N Engl J Med 326 : 455 ~ 465
2. [학술지(정기간행물)] - Jensen OM. / 1990 / Cancer in the European Community and its member states / Eur J Cancer 26 : 1167 ~ 1256
3. [학술지(정기간행물)] - Hruban RH. / 2000 / Progression model for pancreatic cancer / Clin Cancer Res 6 : 2969 ~ 2972
4. [학술지(정기간행물)] - Scholzen T. / 2000 / The Ki-67 protein : from the known and the unknown / J Cell Physiol 182 : 311 ~ 322
5. [학술지(정기간행물)] - Jalava P. / 2006 / Ki67 immunohistochemistry : a valuable marker in prognostication but with a risk of misclassification : proliferation subgroups formed based on Ki67 immunoreactivity and standardized mitotic index / Histopathology 48 : 674 ~ 682
2. [학술지(정기간행물)] - Jensen OM. / 1990 / Cancer in the European Community and its member states / Eur J Cancer 26 : 1167 ~ 1256
3. [학술지(정기간행물)] - Hruban RH. / 2000 / Progression model for pancreatic cancer / Clin Cancer Res 6 : 2969 ~ 2972
4. [학술지(정기간행물)] - Scholzen T. / 2000 / The Ki-67 protein : from the known and the unknown / J Cell Physiol 182 : 311 ~ 322
5. [학술지(정기간행물)] - Jalava P. / 2006 / Ki67 immunohistochemistry : a valuable marker in prognostication but with a risk of misclassification : proliferation subgroups formed based on Ki67 immunoreactivity and standardized mitotic index / Histopathology 48 : 674 ~ 682
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UCI(KEPA) : I410-ECN-0101-2016-514-001306707