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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Ki-67 has been widely performed and become an important biomarker in worldwide clinics, but the standard cut off value of Ki-67 index in breast cancer is still controversy. The objective study was to understand the Ki-67 in breast cancer subtypes and to investigate relative risk of breast cancer subtypes according to Ki-67 cut off value in Korean breast cancer. Immunohistochemical staining (IHC) for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 index was examined from 123 breast cancer patients. Ki-67 index was significantly overexpressed in PR, ER, and HER2 hormone negative groups. Ki-67 index in Triple negative and HER2 subtypes was shown significantly higher than that in Luminal A and Luminal B subtype. Then, we compared the relative risk of each subtype according to 14% and 20% Ki-67 cut off value, which were applied in most clinics. Especially, 20% Ki-67 cut off value in HER2 and Triple negative subtypes was shown 8.41 fold and 2.83 fold higher relative risk than this in Luminal A subtype. Moreover, Ki-67 index in HER2 2+ or 3+ status showed significantly overexpressed than this in HER2 1+ status. At the 20% Ki-67 cut off value, HER2 1+ or 2+ status and 3+ status showed significant difference. Therefore, the 20% Ki-67 cut off value will be useful as a precise prognostic management and helpful for interpreting diverse outcomes of other subtypes in breast cancer patients.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
[학술지(정기간행물)] - Bustreo S / 2016 / Optimal Ki-67 cut-off for luminal breast cancer prognostic evaluation: A large case series study with a long-term follow-up / Breast Cancer Research Treatment 157 : 363 ~ 371
[학술지(정기간행물)] - Cheang MC / 2009 / Ki-67 index, her2 status, and prognosis of patients with luminal B breast cancer / Journal of National Cancer Institute 101 : 736 ~ 750
[학술지(정기간행물)] - 정율리 / 2016 / Interobserver Variability of Ki-67 Measurement in Breast Cancer / Journal of Pathology and Translational Medicine 50 (2) : 129 ~ 137
[학술지(정기간행물)] - Denkert C / 2014 / Reply to Ki-67 in breast cancer: A useful prognostic marker! / Annals of Oncology 25 : 542 ~ 543
[학술지(정기간행물)] - Goldhirsch A / 2011 / Strategies for subtypes--dealing with the diversity of breast cancer: Highlights of the St. Gallen international expert consensus on the primary therapy of early breast cancer 2011 / Annals of Oncology 22 : 1736 ~ 1747
[학술지(정기간행물)] - Cheang MC / 2009 / Ki-67 index, her2 status, and prognosis of patients with luminal B breast cancer / Journal of National Cancer Institute 101 : 736 ~ 750
[학술지(정기간행물)] - 정율리 / 2016 / Interobserver Variability of Ki-67 Measurement in Breast Cancer / Journal of Pathology and Translational Medicine 50 (2) : 129 ~ 137
[학술지(정기간행물)] - Denkert C / 2014 / Reply to Ki-67 in breast cancer: A useful prognostic marker! / Annals of Oncology 25 : 542 ~ 543
[학술지(정기간행물)] - Goldhirsch A / 2011 / Strategies for subtypes--dealing with the diversity of breast cancer: Highlights of the St. Gallen international expert consensus on the primary therapy of early breast cancer 2011 / Annals of Oncology 22 : 1736 ~ 1747
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Roles of Ki67 in Breast Cancer - Important for Management?
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Correlations between HER2 Expression and Other Prognostic Factors in Breast Cancer: Inverse Relations with the Ki-67 Index and P53 Status
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Analysis of the molecular subtypes of preoperative core needle biopsy and surgical specimens in invasive breast cancer
Journal of Pathology and Translational Medicine
2020 .01
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Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma
Annals of Surgical Treatment and Research
2015 .12
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Comparison of Ki-67 and lymphatic invasion as prognostic factor in triple negative early breast cancer
대한외과학회 학술대회 초록집
2017 .11
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Response of Triple Negative Breast Cancer to Neoadjuvant Chemotherapy: Correlation between Ki-67 Expression and Pathological Response
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Relation between Ki-67, ER, PR, Her2/neu, p21, EGFR, and TOP II-α Expression in Invasive Ductal Breast Cancer Patients and Correlations with Prognosis
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Ki67 Frequency in Breast Cancers without Axillary Lymph Node Involvement and its Relation with Disease-free Survival
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Ki-67 and p53 expression as a predictive marker for early postoperative recurrence in pancreatic head cancer
Annals of Surgical Treatment and Research
2015 .03
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Correlation of Preoperative Ki67 and Serum CA15.3 Levels with Outcome in Early Breast Cancers - a Multi Institutional Study
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Prognostic Effect of Breast Cancer Subtypes in Metastatic Breast Cancer Patients
대한임상종양학회 학술대회지
2015 .02
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The different prognostic impact of age according to individual molecular subtypes in breast cancer
Annals of Surgical Treatment and Research
2022 .09
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Interobserver Variability of Ki-67 Measurement in Breast Cancer
Journal of Pathology and Translational Medicine
2016 .01
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Ki-67 Can Predict the Response to the Gemcitabine, Oxaliplatin And L-asparaginase Regimen (GELOX) and Prognosis in Patients with Nasal Natural Killer/T-cell Lymphoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Organ-Specific Recurrence or Metastatic Pattern of Breast Cancer according to Biological Subtypes and Clinical Characteristics
Journal of Breast Disease
2019 .01
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Reliability of Core Needle Biopsy in Evaluating Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2, and Ki-67 Status
Journal of Breast Disease
2016 .12
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Survival Improvement in Korean Breast Cancer Patients Due to Increases in Early-Stage Cancers and Hormone Receptor Positive/HER2 Negative Subtypes: A Nationwide Registry-Based Study
Journal of Breast Cancer
2015 .01
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The Outcomes and Recurrence Patterns According to Breast Cancer Subtypes in Korean Women
대한임상종양학회 학술대회지
2015 .02
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Ultrasonographic Features of Triple-Negative Breast Cancer: a Comparison with Other Breast Cancer Subtypes
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Ki-67 labeling index as a prognostic marker in advanced stomach cancer
Annals of Surgical Treatment and Research
2019 .01
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UCI(KEPA) : I410-ECN-0101-2018-510-001903486