Relation between Ki-67, ER, PR, Her2/neu, p21, EGFR, and TOP II-α Expression in Invasive Ductal Breast Cancer Patients and Correlations with Prognosis

Yan, Jian; Liu, Xiao-Long; Han, Lu-Zhe; Xiao, Gang; Li, Ning-Lei; Deng, Yi-Nan; Yin, Liang-Chun; Ling, Li-Juan; Yu, Xiao-Yuan; Tan, Can-Liang; Huang, Xiao-Ping; Liu, Li-Xin

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자료유형: 학술저널

저자정보: Yan, Jian (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) Liu, Xiao-Long (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) Han, Lu-Zhe (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) Xiao, Gang (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) Li, Ning-Lei (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) Deng, Yi-Nan (Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University) Yin, Liang-Chun (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) Ling, Li-Juan (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) Yu, Xiao-Yuan (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) Tan, Can-Liang (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) Huang, Xiao-Ping (Department of General Surgery, Th) Liu, Li-Xin

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제2호

발행연도: 2015.1

수록면: 823 - 829 (7page)

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The aim of the present study was to investigate the expression of the transcription factor Ki-67, ER, PR, Her2/neu, p21, EGFR, and TOP II-${\alpha}$ in the tumor tissue of patients with invasive ductal carcinoma(IDC); in addition, we examined correlations between these markers. Two hundred and sixteen IDC patients, who were not previously been treated with chemo- or radiotherapy, were included in the study. All tumors were grade I-III. Expression of molecular markers was determined by immunohistochemical analysis on paraffin-embedded tissue sections. Follow-up data were collected for 3 months to 10 years and analyzed for tumor recurrence, survival time, and prognostic risk factors. We determined Ki-67 expression correlates with the expression of ER, PR, HER-2, EGFR, and TOP-${\alpha}$, as well as lymph node involvement, high tumor grade, lymphovascular invasion, high tumor stage, and high TNM stage in IDC. Positive Ki-67 expression was a risk factor for rapid tumor recurrence and may help tumor progression, leading to poor prognosis in IDC. Ki-67 was directly correlated with EGFR, TOP II-${\alpha}$, lymph node involvement, high tumor grade, lymphovascular invasion, high tumor stage, and high TNM stage in the hormone receptor subtypes of breast cancer. In triple negative breast cancer, Ki-67 correlated with TOP II-${\alpha}$. Expression of Ki-67 correlated with that of ER, PR, HER-2, EGFR, TOP II-${\alpha}$, and p21. In addition, the biomarker Ki-67 has a role as a prognostic factor and indicates a poor prognosis in IDC.

#Ki-67 #invasive ductal breast cancer #prognosis

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Yan, Jian

소속기관 Department of General Surgery, The Third Affiliated Hospital of Southern Medical University