지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.20 No.2
- 발행연도
- 2015.6
- 수록면
- 83 - 87 (5page)
이용수
초록· 키워드
오류제보하기
Omega-3, a polyunsaturated fatty acid, is an essential fatty acid necessary for human health, and it protects against cardiovascular disease, inflammation, autoimmune diseases, and cancer. In the present study, we investigated the effects of omega-3-rich harp seal oil (HSO) on the production of nitric oxide (NO) and cytokines, such as tumor necrosis factor (TNF)-α, interleukin-(IL)-1β, IL-6, and IL-12/IL-23 (p40) in peritoneal macrophages of mice. The culture supernatants of murine macrophages exposed to lipopolysaccharide (LPS), HSO, or HSO+LPS were harvested to assay IL-1 β, TNF-α, IL-6, and IL-12/IL-23 (p40) cytokines and NO. TNF-α, IL-1β, and IL-12/IL-23 (p40) levels, except IL-6, were lower in the culture supernatants of mouse peritoneal macrophages exposed to LPS plus HSO than those of the groups exposed to LPS alone. These observations demonstrate that omega-3-rich harp seal oil downregulates the production of the pro-inflammatory cytokines such as IL-1β, TNF-α, and IL-12/IL-23 (p40). These results suggest that HSO could be potentially used as a preventive agent or as an adjunct in anti-inflammatory therapy, if more research results were accumulated.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] - Dyerberg J / 1975 / Fatty acid composition of the plasma lipids in Greenland Eskimos / Am J Clin Nutr 28 : 958 ~ 966
[학술지(정기간행물)] - Simopoulos AP / 2002 / Omega-3 fatty acids in inflammation and autoimmune diseases / J Am Coll Nutr 21 : 495 ~ 505
[학술지(정기간행물)] - Calder PC. / 2006 / n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases / Am J Clin Nutr 83 : 1505S ~ 1519S
[학술지(정기간행물)] - Ross R / 1999 / Atherosclerosis-an inflammatory disease / N Engl J Med 340 : 115 ~ 126
[학술지(정기간행물)] - Arrington JL / 2001 / Docosahexaenoic acid suppresses function of the CD28 costimulatory membrane receptor in primary murine and Jurkat T cells / J Nutr 131 : 1147 ~ 1153
[학술지(정기간행물)] - Simopoulos AP / 2002 / Omega-3 fatty acids in inflammation and autoimmune diseases / J Am Coll Nutr 21 : 495 ~ 505
[학술지(정기간행물)] - Calder PC. / 2006 / n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases / Am J Clin Nutr 83 : 1505S ~ 1519S
[학술지(정기간행물)] - Ross R / 1999 / Atherosclerosis-an inflammatory disease / N Engl J Med 340 : 115 ~ 126
[학술지(정기간행물)] - Arrington JL / 2001 / Docosahexaenoic acid suppresses function of the CD28 costimulatory membrane receptor in primary murine and Jurkat T cells / J Nutr 131 : 1147 ~ 1153
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UCI(KEPA) : I410-ECN-0101-2016-594-001674208