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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.20 No.2
- 발행연도
- 2015.6
- 수록면
- 94 - 101 (8page)
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Grape products have been known to exert greater antioxidant and anti-obesity than anti-hyperglycemic effects in animals and humans. Omija is used as an ingredient in traditional medicine, and it is known to have an anti-hyperglycemic effect. We investigated whether the combined extracts of grape pomace and omija fruit (GE+OE) could reduce fat accumulation in adipose and hepatic tissues and provide beneficial effects against hyperglycemia and insulin resistance in type 2 diabetic mice. C57BL/KsJ-db/db mice were fed either a normal control diet or GE+OE (0.5% grape pomace extract and 0.05% omija fruit extract, w/w) for 7 weeks. GE+OE decreased plasma leptin and resistin levels while increasing adiponectin levels and reducing the total white adipose tissue weight. Furthermore, GE+OE lowered plasma free fatty acid (FFA), triglyceride, and total-cholesterol levels as well as hepatic FFA and cholesterol levels. Hepatic fatty acid synthase and glucose 6-phosphate dehydrogenase activities were decreased in the GE+E group, whereas hepatic β-oxidation activity was increased. Furthermore, GE+OE supplementation not only reduced hyperglycemia and pancreatic β-cell failure but also lowered blood glycosylated hemoglobin and plasma insulin levels. The homeostasis model assessment of insulin resistance levels was also decreased and the decrease seems to be mediated by the lowered activities of hepatic glucose-6-phosphatase and phosphoenolpyruvate carboxykinases. The present data suggest that GE+OE may have the potential to reduce hyperglycemia, insulin resistance, and obesity in patients with type 2 diabetes.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (45)
참고문헌 신청
[학술지(정기간행물)] - Leahy JL / 2005 / Pathogenesis of type 2 diabetes mellitus / Arch Med Res 36 : 197 ~ 209
[학술지(정기간행물)] - Matsuzawa Y / 1999 / Molecular mechanism of metabolic syndrome X : contribution of adipocytokines · adipocyte-derived bioactive substances / Ann NY Acad Sci 892 : 146 ~ 154
[학술지(정기간행물)] - Roden M / 1996 / Mechanism of free fatty acid-induced insulin resistance in humans / J Clin Invest 97 : 2859 ~ 2865
[학술지(정기간행물)] - Rajala MW / 2003 / Minireview : The adipocyte−at the crossroads of energy homeostasis, inflammation, and atherosclersis / Endocrinology 144 : 3765 ~ 3773
[학술지(정기간행물)] - Michael MD / 2000 / Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction / Mol Cell 6 : 87 ~ 97
[학술지(정기간행물)] - Matsuzawa Y / 1999 / Molecular mechanism of metabolic syndrome X : contribution of adipocytokines · adipocyte-derived bioactive substances / Ann NY Acad Sci 892 : 146 ~ 154
[학술지(정기간행물)] - Roden M / 1996 / Mechanism of free fatty acid-induced insulin resistance in humans / J Clin Invest 97 : 2859 ~ 2865
[학술지(정기간행물)] - Rajala MW / 2003 / Minireview : The adipocyte−at the crossroads of energy homeostasis, inflammation, and atherosclersis / Endocrinology 144 : 3765 ~ 3773
[학술지(정기간행물)] - Michael MD / 2000 / Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction / Mol Cell 6 : 87 ~ 97
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UCI(KEPA) : I410-ECN-0101-2016-594-001674228