Prevalence of Human Papillomavirus Genotypes in Routine Pap Smear of 2,562 Korean Women Determined by PCR-DNA Sequencing

Kyung-Ok Lee; Su-Jin Jeong; Min-Young Park; Hye-Soon Seong; Eun-Sim Shin; Kyeong-Hwan Choi; Gee-Young Kim; Sun-Hwa Lee

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자료유형: 학술저널

저자정보: Kyung-Ok Lee (네오딘의학연구소) Su-Jin Jeong (네오딘의학연구소) Min-Young Park (네오딘의학연구소) Hye-Soon Seong (네오딘의학연구소) Eun-Sim Shin (네오딘의학연구소) Kyeong-Hwan Choi (네오딘의학연구소) Gee-Young Kim (네오딘의학연구소) Sun-Hwa Lee (네오딘의학연구소)

저널정보: 대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY Journal of Bacteriology and Virology 제39권 제4호

발행연도: 2009.12

수록면: 337 - 344 (8page)

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The infections by human papillomaviruses (HPVs) are clearly associated with the subsequent development of cervical cancer. In this study, HPV genotype distribution and prevalence were detected in Korean women from January to December 2008 using PCR-DNA sequencing. A total of 2,562 cervical samples from Korean women having routine Pap smear cytology screening were used. HPV DNA was extracted from cervical swab samples and amplified by PCR in L1 region of HPV. HPV DNA was detected in 23.2% and 65.5% from the groups of normal and abnormal Pap cytology, respectively. The prevalence of high-risk types of HPV had the highest frequency in the ＜30 year-olds' group (50.6%). The prevalence of HPV in normal, ASCUS, LSIL and HSIL groups was 23.2%, 58.1%, 96.3% and 97.0%, respectively. Moreover, the frequencies of the high-risk types of HPV were 16.2% in the normal Pap cytology, 44.7% in the ASCUS, 76.1% in the LSIL and 94.1% in the HSIL groups. The prevalence of the high-risk types of HPV increased in proportion to the severity of the cytological classification. In the HSIL group, HPV type 16 was the most frequently found at 32.4%, followed by types 58, 53 and 33 at 17.6%, 14.7% and 11.8%, respectively. HPV type 82 was found in 5.6% of the HSIL group and was not detected in the normal Pap cytology group. The frequency of high-risk type of HPV 82 is firstly reported in Korean women. This finding could be an informative basis for the development of future HPV vaccination strategies in Korean women.

#HPV genotype #Prevalence #PCR-DNA sequencing

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주요연구분야 자연과학 > 생물학 의약학 > 기초의학 > 미생물학

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Su-Jin Jeong

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