지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.9
- 수록면
- 210 - 216 (7page)
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The structure of coxsackievirus and adenovirus receptor"s CAR is similar to adhesion molecules. In the adult heart, the majority of CAR localizes at the intercalated disc. Germ line CAR deletion induces embryonic lethality at E11.5 with evidence of a cardiac abnormality. The CAR role as a viral receptor is well known; however, its precise function in the heart for enterovirus infection is not clear. To understand the role of CAR in the cardiac myocyte, we generated cardiac-specific CAR knockout mice using a CAR floxed allele and alpha-MHC-Mer CRE Mer mice. Western blot analysis and immunofluorescent stain of ventricles at 6 weeks after 2 weeks tamoxifen administration, CAR expression was significantly decreased in CAR<SUP>f/f</SUP> MCM mice but not in CAR<SUP>f/f</SUP> mice heart. Enterovirus was intraperitoneally infected into CAR<SUP>f/f</SUP> MCM and CAR<SUP>f/f</SUP> mice (n=10 each). CAR disruption was dramatically reduced virus infection and replication in the heart but not different in liver, spleen, and pancreas. Cardiac myocyte damage was significantly reduced in the CAR<SUP>f/f</SUP> MCM mutant mice by evans blue dye stain. In addition, the CAR<SUP>f/f </SUP> MCM mutant mice heart inflammation and fibrosis were decreased in H&E and trichrome stain compare to CAR<SUP>f/f</SUP> control mice. CAR expression was required for normal ventricular function, but it is the cause of enterovirus infection. In the adult mice heart, CAR deletion was significantly reduced viral infection, proliferation, and myocarditis. These results suggested that CAR deletion could be useful therapeutic strategy to prevent viral myocarditis.
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참고문헌
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Bergelson JM / 1997 / Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5 / Science 275 : 1320 ~ 1323
2. [학술지(정기간행물)] - Lim BK / 2008 / Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart / Clin Invest 118 : 2758 ~ 2770
3. [학술지(정기간행물)] - Baboonian C / 1997 / Coxsackie B viruses and human heart disease / Curr Top Microbiol Immunol 223 : 31 ~ 52
4. [학술지(정기간행물)] - Lim BK / 2006 / Virus receptor trap neutralizes coxsackievirus in experimental murine viral myocarditis / Cardiovasc Res 71 : 517 ~ 526
5. [학술지(정기간행물)] - Coyne CB / 2005 / CAR: a virus receptor within the tight junction / Adv Drug Deliv Rev 57 : 869 ~ 882
2. [학술지(정기간행물)] - Lim BK / 2008 / Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart / Clin Invest 118 : 2758 ~ 2770
3. [학술지(정기간행물)] - Baboonian C / 1997 / Coxsackie B viruses and human heart disease / Curr Top Microbiol Immunol 223 : 31 ~ 52
4. [학술지(정기간행물)] - Lim BK / 2006 / Virus receptor trap neutralizes coxsackievirus in experimental murine viral myocarditis / Cardiovasc Res 71 : 517 ~ 526
5. [학술지(정기간행물)] - Coyne CB / 2005 / CAR: a virus receptor within the tight junction / Adv Drug Deliv Rev 57 : 869 ~ 882
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