지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.3
- 수록면
- 45 - 49 (5page)
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초록· 키워드
오류제보하기
Inflammation in the brain has known to be associated with the development of a various neurological diseases. The hallmark of neuro-inflammation is the activation of microglia, brain macrophage. Pro-inflammatory compounds including nitric oxide (NO) are the main cause of neuro-degenerative disease such as Alzheimer's disease (AD) which is resulted in cell death. Among those pro-inflammatory compounds, NO contributes to the cell death by directly or indirectly. Methods: In the study, we examined whether ursodeoxycholic acid (UDCA), a non-toxic hydrophilic bile acid, inhibits the NO production by a direct method using Griess reagent and by RT-PCR in the gene expression of inducible nitric oxide synthase (iNOS). In signal transduction, we also examined the NF-κB (p65/p50), IKK, and I κB , which are associated with the expression of iNOS gene using western blots. Results: In the present study, we found that UDCA effectively inhibited NO production in BV-2 microglial cell, and NF-κB activation was reduced by suppressing IKK gene expression and by increasing the IκB in cytosol comparing those to the positive control LPS. Conclusion: Taken together, these data suggested that UDCA may playa crucial role in inhibiting the NO production and the results imply that UDCA suppresses a cue signal of the microglial activation via stimulators, such as β-amyloid peptides which are known to stimulate microglia in AD pathogenesis.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
[학술지(정기간행물)] - / 2001 / NF-kappaB in transplantation friend or foe. Transpl Infect Dis 3 : 212 ~ 219
[학술지(정기간행물)] - / 1999 / Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol. 39 39 : 191 ~ 220
[학술지(정기간행물)] - / 2004 / Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation. FEBS Lett 571 571 : 50 ~ 54
[학술지(정기간행물)] - / 2004 / key regulators of the NF-kappaB pathway. Trends Biochem Sci 29 : 72 ~ 79
[학술지(정기간행물)] - / 1996 / a sensor for pathological events in the CNS. Trends Neurosci 19 : 312 ~ 318
[학술지(정기간행물)] - / 1999 / Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol. 39 39 : 191 ~ 220
[학술지(정기간행물)] - / 2004 / Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation. FEBS Lett 571 571 : 50 ~ 54
[학술지(정기간행물)] - / 2004 / key regulators of the NF-kappaB pathway. Trends Biochem Sci 29 : 72 ~ 79
[학술지(정기간행물)] - / 1996 / a sensor for pathological events in the CNS. Trends Neurosci 19 : 312 ~ 318
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Anti-Inflammatory Effect on Rat Microglia by UDCA
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A Pharmacological Advantage of Ursodeoxycholic Acid in Cytoprotection in Primary Rat Microglia
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Inhibitory Action of Minocycline on Lipopolysaccharide-Induced Release of Nitric Oxide and Prostaglandin E2 in BV2 Microglial Cells
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Potential Role of Ursodeoxycholic Acid in Suppression of Nuclear Factor Kappa B in Microglial Cell Line (BV-2)
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지질다당체유도 BV2세포손상에 대한 상백피 추출물의 항염증작용
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Ursodeoxycholic Acid Ameliorates Pain Severity and Cartilage Degeneration in Monosodium Iodoacetate-Induced Osteoarthritis in Rats
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Protein Kinase C-αRegulates Toll-like Receptor 4-Mediated Inducible Nitric Oxide Synthase Expression
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2008 .01
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삼묘환(三妙丸)의 LPS에 의해 활성화된 RAW 264.7 cells과 BV-2 Microglia cells로부터 생성되는 nitric oxide 및 $TNF-{\alpha}$의 생성억제효과
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2006 .01
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Ceramide analogs inhibit inducible nitric oxide synthase expression and nitric oxide production in interferon-gamma and lipopolysaccharide-stimulated RAW 264.7 macrophages.
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Induction of Apoptosis in HepG2 Human Hepatocellular Carcinoma Cells by a Novel Derivative of Ursodeoxycholic Acid (UDCA)
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Pretreatment of Macrophages with Paclitaxel Inhibits iNOS Expression
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2006 .06
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