지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.9
- 수록면
- 90 - 97 (8page)
이용수
초록· 키워드
오류제보하기
Hypersensitivity pneumonitis (HP) comprises a group of lung diseases resulting from repeated inhalation of various antigens such as Saccharopolyspora rectivirgula (SR). HP is categorized as a Th1 disease. Therefore, it has been suggested that IL-4, Th2 type cytokine, plays a protective role in the development of HP. However, the functional role of IL-4 in HP has not been extensively investigated in vivo. Therefore, we investigated the functional role of IL-4 in HP using IL-4 knockout (KO) mice. Methods: HP was induced by repeated exposure to SR in C57BL/6 (B6) and IL-4 KO (C57BL/6 background) mice. Results: IL-4 KO mice aggravated HP in terms of histological alteration, SR-specific immune responses, and inflammatory cell infiltration in the lungs compared with B6 mice. IL-4 KO mice produced high levels of IFN-γ, TGF-β and TNF-α in the lungs, whereas B6 mice showed the enhanced production of IL-4. Moreover, chemokines such as MIP-1α, MCP-1, and RANTES were highly expressed in IL-4 KO mice. IFN-γ-secreting CD4, CD8 T cells, and neutrophils were enhanced in the bronchoalveolar lavage fluid (BALF) of IL-4 KO mice than those of B6 mice. The administration of recombinant(r) IL-4 restored these immunologic parameters in IL-4 KO mice. Conclusion: These results indicate that IL-4 plays a suppressive role in SR-induced HP by attenuating Th1-dominant immune responses.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Takizawa H / 1988 / Experimental hypersensitivity pneumonitis in the mouse: histologic and immunologic features and their modulation with cyclosporin A / J Allergy Clin Immunol 81 : 391 ~ 400
2. [학술지(정기간행물)] - Reijula KE / 1993 / Two bacteria causing farmer's lung: fine structure of Thermoactinomyces vulgaris and Saccharopolyspora rectivirgula / Mycopathologia 121 : 143 ~ 147
3. [학술지(정기간행물)] - Keller RH / 1982 / Immunoregulation in hypersensitivity pneumonitis. I. Differences in T-cell and macrophage suppressor activity in symptomatic and asymptomatic pigeon breeders / J Clin Immunol 2 : 46 ~ 54
4. [학술지(정기간행물)] - Sharma OP / 1995 / Fujimura N: Hypersensitivity pneumonitis: a noninfectious granulomatosis / Semin Respir Infect 10 : 96 ~ 106
5. [학술지(정기간행물)] - Denis M / 1992 / T cells in hypersensitivity pneumonitis: effects of in vivo depletion of T cells in a mouse model / Am J Respir Cell Mol Biol 6 : 183 ~ 189
2. [학술지(정기간행물)] - Reijula KE / 1993 / Two bacteria causing farmer's lung: fine structure of Thermoactinomyces vulgaris and Saccharopolyspora rectivirgula / Mycopathologia 121 : 143 ~ 147
3. [학술지(정기간행물)] - Keller RH / 1982 / Immunoregulation in hypersensitivity pneumonitis. I. Differences in T-cell and macrophage suppressor activity in symptomatic and asymptomatic pigeon breeders / J Clin Immunol 2 : 46 ~ 54
4. [학술지(정기간행물)] - Sharma OP / 1995 / Fujimura N: Hypersensitivity pneumonitis: a noninfectious granulomatosis / Semin Respir Infect 10 : 96 ~ 106
5. [학술지(정기간행물)] - Denis M / 1992 / T cells in hypersensitivity pneumonitis: effects of in vivo depletion of T cells in a mouse model / Am J Respir Cell Mol Biol 6 : 183 ~ 189
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