지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.10
- 수록면
- 232 - 240 (9page)
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초록· 키워드
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The triggering receptor expressed on myeloid cells (TREM) family, which is abundantly expressed in myeloid lineage cells, plays a pivotal role in innate and adaptive immune response. In this study, we aimed to identify a novel receptor expressed on hematopoietic stem cells (HSCs) by using in silico bioinformatics and to characterize the identified receptor. We thus found the TREM-like transcript (TLT)-6, a new member of TREM family. TLT-6 has a single immunoglobulin domain in the extracellular region and a long cytoplasmic region containing 2 immunoreceptor tyrosine-based inhibitory motif-like domains. TLT-6 transcript was expressed in HSCs, monocytes and macrophages. TLT-6 protein was up-regulated on the surface of bone marrow-derived and peritoneal macrophages by lipopolysaccharide stimulation. TLT-6 exerted anti-proliferative effects in macrophages. Our results demonstrate that TLT-6 may regulate the activation and proliferation of macrophages.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] - Ford, J. W. / 2009 / TREM TREM-like receptors in inflammation disease / Curr. Opin. Immunol 21 : 38 ~ 46
[학술지(정기간행물)] - Klesney-Tait, J. / 2006 / The TREM receptor family signal integration / Nat. Immunol 7 : 1266 ~ 1273
[학술지(정기간행물)] - Zanzinger, K. / 2009 / Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes / Immunology 128 : 185 ~ 195
[학술지(정기간행물)] - Kusanovic, J. P. / 2010 / Amniotic fluid sTREM-1 in normal pregnancy, spontaneous parturition at term preterm, intra-amniotic infection/inflammation / J. Matern. Fetal Neonatal Med 23 : 34 ~ 47
[학술지(정기간행물)] - Turnbull, I. R. / 2006 / Cutting edge:TREM-2 attenuates macrophage activation / J. Immunol 177 : 3520 ~ 3524
[학술지(정기간행물)] - Klesney-Tait, J. / 2006 / The TREM receptor family signal integration / Nat. Immunol 7 : 1266 ~ 1273
[학술지(정기간행물)] - Zanzinger, K. / 2009 / Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes / Immunology 128 : 185 ~ 195
[학술지(정기간행물)] - Kusanovic, J. P. / 2010 / Amniotic fluid sTREM-1 in normal pregnancy, spontaneous parturition at term preterm, intra-amniotic infection/inflammation / J. Matern. Fetal Neonatal Med 23 : 34 ~ 47
[학술지(정기간행물)] - Turnbull, I. R. / 2006 / Cutting edge:TREM-2 attenuates macrophage activation / J. Immunol 177 : 3520 ~ 3524
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UCI(KEPA) : I410-ECN-0101-2016-511-002009673