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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.8
- 수록면
- 167 - 176 (10page)
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초록· 키워드
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Macrophages are the main effector cells of innate immunity and are involved in inflammatory and anti-infective processes. They also have an essential role in maintaining tissue homeostasis, supporting tissue development, and repairing tissue damage. Until few years ago, it was believed that tissue macrophages derived from circulating blood monocytes, which terminally differentiated in the tissue and unable to proliferate. Recent evidence in the biology of tissue macrophages has uncovered a series of immune and ontogenic features that had been neglected for long, despite old observations. These include origin, heterogeneity, proliferative potential (or self-renewal), polarization, and memory. In recent years, the number of publications on tissue resident macrophages has grown rapidly, highlighting the renewed interest of the immunologists for these key players of innate immunity. This minireview aims to summarizing the new current knowledge in macrophage immunobiology, in order to offer a clear and immediate overview of the field.
목차
INTRODUCTION
DUAL ORIGIN, PROLIFERATIVE POTENTIAL AND HETEROGENEITY OF TISSUE MACROPHAGES
MACROPHAGE POLARIZATION
TISSUE-SPECIFIC SIGNALS DICTATE FUNCTIONAL SPECIALIZATION AND POLARIZATION OF TISSUE MACROPHAGE
A RENEWED INTEREST FOR INNATE MEMORY
CONCLUDING REMARKS
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2016-511-001834823