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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 273 - 282 (10page)
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초록· 키워드
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Chronic hyperglycemia is the primary risk factor for the development of complications in diabetes mellitus (DM); however, it is believed that frequent or large glucose fluctuations may independently contribute to diabetes-related complications. Postprandial spikes in blood glucose, as well as hypoglycemic events, are blamed for increased cardiovascular events in DM. Glycemic variability (GV) includes both of these events; hence, minimizing GV can prevent future cardiovascular events. Correcting GV emerges as a target to be pursued in clinical practice to safely reduce the mean blood glucose and to determine its direct effects on vascular complications in diabetes. Modern diabetes management modalities, including glucagon-related peptide-1-based therapy, newer insulins, modern insulin pumps and bariatric surgery, significantly reduce GV. However, defining GV remains a challenge primarily due to the difficulty of measuring it and the lack of consensus regarding the optimal approach for its management. The purpose of this manuscript was not only to review the most recent evidence on GV but also to help readers better understand the available measurement options and how the various definitions relate differently to the development of diabetic complications.
목차
등록된 정보가 없습니다.
참고문헌 (63)
참고문헌 신청
Frontoni S / 2013 / Glucose variability: an emerging target for the treatment of diabetes mellitus / Diabetes Res Clin Pract 102:86~95
Wang C / 2012 / Glucose fluctuations in subjects with normal glucose tolerance, impaired glucose regulation and newly diagnosed type 2 diabetes mellitus / Clin Endocrinol (Oxf) 76:810~815
Siegelaar SE / 2011 / A decrease in glucose variability does not reduce cardiovascular event rates in type 2 diabetic patients after acute myocardial infarction: a reanalysis of the HEART2D study / Diabetes Care 34:855~857
Cavalot F / 2006 / Postprandial blood glucose is a stronger predictor of cardiovascular events than fasting blood glucose in type 2 diabetes mellitus, particularly in women: lessons from the San Luigi Gonzaga Diabetes Study / J Clin Endocrinol Metab 91:813~819
Muggeo M / 2000 / Fasting plasma glucose variability predicts 10-year survival of type 2 diabetic patients: the Verona Diabetes Study / Diabetes Care 23:45~50
Wang C / 2012 / Glucose fluctuations in subjects with normal glucose tolerance, impaired glucose regulation and newly diagnosed type 2 diabetes mellitus / Clin Endocrinol (Oxf) 76:810~815
Siegelaar SE / 2011 / A decrease in glucose variability does not reduce cardiovascular event rates in type 2 diabetic patients after acute myocardial infarction: a reanalysis of the HEART2D study / Diabetes Care 34:855~857
Cavalot F / 2006 / Postprandial blood glucose is a stronger predictor of cardiovascular events than fasting blood glucose in type 2 diabetes mellitus, particularly in women: lessons from the San Luigi Gonzaga Diabetes Study / J Clin Endocrinol Metab 91:813~819
Muggeo M / 2000 / Fasting plasma glucose variability predicts 10-year survival of type 2 diabetic patients: the Verona Diabetes Study / Diabetes Care 23:45~50
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