지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 181 - 187 (7page)
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초록· 키워드
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Osteoporosis is one of the diseases caused by accumulation of effects from complex interactions between genetic and environmental factors. Aging is the major cause for osteoporosis, which normally increases skeletal fragility and bone fracture especially among the elder. "Omics" refers to a specialized research field dealing with high-throughput biological data, such as genomics, transcriptomics, proteomics or metabolomics. Integration of data from multi-omics has been approved to be a powerful strategy to colligate biological phenomenon with multiple aspects. Actually, integrative analyses of "omics" datasets were used to present pathogenesis of specific diseases or casual biomarkers including susceptible genes. In this study, we evaluated the proposed relationship of novel susceptible genes (TREML2, HTR1E, and GLO1) with osteoporosis, which genes were obtained using multi-omics integration analyses. To this end, SNPs of the susceptible genes in the Korean female cohort were analyzed. As a result, one SNP of HTR1E and five SNPs of TREML2 were identified to associate with osteoporosis. The highest significant SNP was rs6938076* of TREML2 (OR=0.63, CI: 0.45~0.89, recessive P=0.009). Consequently, the susceptible genes identified through the multi-omics analyses were confirmed to have association with osteoporosis. Therefore, multi-omics analysis might be a powerful tool to find new genes associated with a disease. We further identified that TREML2 has more associated with osteoporosis in females than did HTR1E.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (21)
참고문헌 신청
[학술지(정기간행물)] - Cho YS / 2009 / A large-scale genome-wide association study of asian populations uncovers genetic factors influencing eight quantitative traits / Nat Genet 41 : 527 ~ 534
[학술지(정기간행물)] - Dhanwal DK / 2011 / Epidemiology of hip fracture: Worldwide geographic variation / Indian J Orthop 45 : 15 ~ 22
[학술지(정기간행물)] - International HapMap Consortium / 2003 / The international HapMap project / Nature 426 : 789 ~ 796
[학술지(정기간행물)] - 진현석 / 2012 / Replicated Association between SLC4A4 Gene and Blood Pressure Traits in the Korean Population / 대한의생명과학회지 18 (4) : 377 ~ 383
[학술지(정기간행물)] - 진현석 / 2012 / Genetic Variations of ESR1 Gene are Associated with Bone Mineral Density Traits in Korean Women / 대한의생명과학회지 18 (3) : 244 ~ 253
[학술지(정기간행물)] - Dhanwal DK / 2011 / Epidemiology of hip fracture: Worldwide geographic variation / Indian J Orthop 45 : 15 ~ 22
[학술지(정기간행물)] - International HapMap Consortium / 2003 / The international HapMap project / Nature 426 : 789 ~ 796
[학술지(정기간행물)] - 진현석 / 2012 / Replicated Association between SLC4A4 Gene and Blood Pressure Traits in the Korean Population / 대한의생명과학회지 18 (4) : 377 ~ 383
[학술지(정기간행물)] - 진현석 / 2012 / Genetic Variations of ESR1 Gene are Associated with Bone Mineral Density Traits in Korean Women / 대한의생명과학회지 18 (3) : 244 ~ 253
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UCI(KEPA) : I410-ECN-0101-2016-510-002321973