지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.38 No.1
- 발행연도
- 2023.3
- 수록면
- 28 - 34 (7page)
이용수
초록· 키워드
오류제보하기
Heavy metals such as lead (Pb) and cadmium (Cd) exist as particulate matter (PM) in the air and can cause biological damage to cells, animals, and humans. However, the mechanism underlying the toxic effects of heavy metals on nerve cells has not yet been completely identified. Glioma is the most common and fatal tumor in the central nervous system; the U87 human glioblastoma cell line is commonly used when researching brain cancer, including aggressive malignant gliomas. Therefore, in this study, cell viability, cytotoxicity, and interleukin-6 (IL-6) levels were analyzed to confirm the effect of Cd and Pb exposure on U87 cells. On confirming the absence of significant effects on cell viability at low concentrations of heavy metals, Cd and Pb exposure had no effect on lactic acid dehydrogenase (LDH) activity at the concentrations (1 μg/L, 30 μg/L, and 1 mg/L) used in this study, and there was a remarkable effect of Cd and Pb exposure on the inflammatory response of these cells. Our findings provide a basis for future research elucidating the effects of heavy metal exposure on cellular pathology. Systematic studies with higher heavy metal concentrations and precision are warranted to deepen our understanding of the relationship between heavy metal exposure and neuronal responses.
목차
Abstract
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (20)
참고문헌 신청
Qian-wen W, Jeon JS, Kim JK. Effects of heavy metals on the viability of A549 cells. Indian Journal of Biochemistry and Biophysics 2022;59:726-731.
Diaz-Ortiz ME, Chen-Plotkin AS. Omics in neurodegenerative disease: Hope or hype? Trends Genet 2020;36(3):152-159. https://doi.org/10.1016/j.tig.2019.12.002
Hussien HM, Ghareeb DA, Ahmed HEA, Hafez HS, Saleh SR. Pharmacological implications of ipriflavone against environmental metal–induced neurodegeneration and dementia in rats. Environ Sci Pollut Res Int 2021;28(46):65349-65362. https://doi.org/10.1007/s113
Wu X, Cobbina SJ, Mao G, Xu H, Zhang Z, Yang L. A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment. Environ Sci Pollut Res Int 2016;23(9):8244-8259. https://doi.org/10.1007/s11356-016-6333-x
Boskabady M, Marefati N, Farkhondeh T, Shakeri F, Farshbaf A, Boskabady MH. The effect of environmental lead exposure on human health and the contribution of inflammatory mechanisms, a review. Environ Int 2018;120:404-420. https://doi.org/10.1016/j.envint
Diaz-Ortiz ME, Chen-Plotkin AS. Omics in neurodegenerative disease: Hope or hype? Trends Genet 2020;36(3):152-159. https://doi.org/10.1016/j.tig.2019.12.002
Hussien HM, Ghareeb DA, Ahmed HEA, Hafez HS, Saleh SR. Pharmacological implications of ipriflavone against environmental metal–induced neurodegeneration and dementia in rats. Environ Sci Pollut Res Int 2021;28(46):65349-65362. https://doi.org/10.1007/s113
Wu X, Cobbina SJ, Mao G, Xu H, Zhang Z, Yang L. A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment. Environ Sci Pollut Res Int 2016;23(9):8244-8259. https://doi.org/10.1007/s11356-016-6333-x
Boskabady M, Marefati N, Farkhondeh T, Shakeri F, Farshbaf A, Boskabady MH. The effect of environmental lead exposure on human health and the contribution of inflammatory mechanisms, a review. Environ Int 2018;120:404-420. https://doi.org/10.1016/j.envint
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UCI(KEPA) : I410-ECN-0101-2023-539-001465732