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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.21 No.1
- 발행연도
- 2016.3
- 수록면
- 31 - 37 (7page)
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Opuntia humifusa (OHF) has been used as a nutraceutical source for the prevention of chronic diseases. In the present study, the inhibitory effects of ethyl acetate extracts of OHF on the proliferation of AGS human gastric cancer cells and the mode of action were investigated. To elucidate the antiproliferative mechanisms of OHF in cancer cells, the expression of genes related to apoptosis and cell cycle arrest were determined with real-time PCR and western blot. The cytotoxic effect of OHF on AGS cells was observed in a dose-dependent manner. Exposure to OHF (100 μg/mL) significantly induced (P＜0.05) the G1 phase cell cycle arrest. Additionally, the apoptotic cell population was greater (P＜0.05) in OHF (200 μg/mL) treated AGS cells when compared to the control. The expression of genes associated with cell cycle progression (Cdk4, Cdk2, and cyclin E) was significantly downregulated (P＜0.05) by the OHF treatment. Moreover, the expression of Bax and caspase-3 in OHF treated cells was higher (P＜0.05) than in the control. These findings suggest that OHF induces the G1 phase cell cycle arrest and activation of mitochondria-mediated apoptosis pathway in AGS human gastric cancer cells.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
Acuña UM, Atha DE, Ma J, Nee MH, Kennelly EJ. 2002. Antioxidant capacities of ten edible North American plants. Phytother Res 16: 63-65.
Kim J, Jho KH, Choi YH, Nam SY. 2013. Chemopreventive effect of cactus (Opuntia humifusa) extracts: radical scavenging activity, pro-apoptosis, and anti-inflammatory effect in human colon (SW480) and breast cancer (MCF7) cells. Food Funct 4: 681-688.
Goldstein G, Nobel PS. 1994. Water relations and low-temperature acclimation for cactus species varying in freezing tolerance. Plant Physiol 104: 675-681.
Hahm SW, Park J, Son YS. 2011. Opuntia humifusa stems lower blood glucose and cholesterol levels in streptozotocin-induced diabetic rats. Nutr Res 31: 479-487.
Lee JA, Jung BG, Kim TH, Lee SG, Park YS, Lee BJ. 2013. Dietary feeding of Opuntia humifusa inhibits UVB radiationinduced carcinogenesis by reducing inflammation and proliferation in hairless mouse model. Photochem Photobiol 89: 1208-1215.
Kim J, Jho KH, Choi YH, Nam SY. 2013. Chemopreventive effect of cactus (Opuntia humifusa) extracts: radical scavenging activity, pro-apoptosis, and anti-inflammatory effect in human colon (SW480) and breast cancer (MCF7) cells. Food Funct 4: 681-688.
Goldstein G, Nobel PS. 1994. Water relations and low-temperature acclimation for cactus species varying in freezing tolerance. Plant Physiol 104: 675-681.
Hahm SW, Park J, Son YS. 2011. Opuntia humifusa stems lower blood glucose and cholesterol levels in streptozotocin-induced diabetic rats. Nutr Res 31: 479-487.
Lee JA, Jung BG, Kim TH, Lee SG, Park YS, Lee BJ. 2013. Dietary feeding of Opuntia humifusa inhibits UVB radiationinduced carcinogenesis by reducing inflammation and proliferation in hairless mouse model. Photochem Photobiol 89: 1208-1215.
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UCI(KEPA) : I410-ECN-0101-2016-594-002777584