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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제59권 제3호
- 발행연도
- 2016.1
- 수록면
- 207 - 213 (7page)
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초록· 키워드
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Little information about the biological activities of Citrus limon (lemon) leaves has been reported, whereas the fruit of Citrus limon (lemon) has been well-documented to contain various pro-health bio-functional compounds. In the present study, the antiproliferative activities of the lemon leaves were evaluated using several cancer cell lines. From the n-hexane, chloroform, ethyl acetate, n-butanol, and water fractions of methanolic extract of the leaves, the chloroform fraction of lemon leaves (CFLL) showed the most potent antiproliferative activity in the AGS human gastric cancer cells. The current study demonstrates that CFLL induces apoptosis in AGS cells, as evidenced by an increase in apoptotic bodies, cell population in the sub-G1 phase, Bax/Bcl-2 ratio, and cleavage of poly (ADP-ribose) polymerase (PARP), caspase-3 and caspase-9. Compositional analysis of the CFLL using gas chromatography mass spectrometry (GC-MS) resulted in the identification of 27 compounds including trans, trans-farnesol (3.19 %), farnesol (3.26 %), vanillic acid (1.45 %), (-)-loliolide (5.24 %) and palmitic acid (6.96 %). Understanding the modes of action of these compounds individually and/or synergistically would provide useful information about their applications in cancer prevention and therapy.
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참고문헌 (34)
참고문헌 신청
Chou TH / 2010 / Antioxidative characteristics and inhibition of α-melanocyte-stimulating hormone-stimulated melanogenesis of vanillin and vanillic acid from Origanum vulgare / Exp Dermatol 19:742~750
Cragg GM / 1997 / Natural products in drug discovery and development / J Nat Prod 60:52~60
da Rocha AB / 2001 / Natural products in anticancer therapy / Curr Opinion Pharmacol 1:364~369
Farnsworth NR / 1985 / Medicinal plants in therapy / Bull World Health Organ 63:965~981
Gamet-Payrastre L / 2000 / Sulforaphane, a naturally occurring isothiocyanate, induce cell cycle arrest and apoptosis in HT29 human colon cancer cells / Cancer Res 60:1426~1433
Cragg GM / 1997 / Natural products in drug discovery and development / J Nat Prod 60:52~60
da Rocha AB / 2001 / Natural products in anticancer therapy / Curr Opinion Pharmacol 1:364~369
Farnsworth NR / 1985 / Medicinal plants in therapy / Bull World Health Organ 63:965~981
Gamet-Payrastre L / 2000 / Sulforaphane, a naturally occurring isothiocyanate, induce cell cycle arrest and apoptosis in HT29 human colon cancer cells / Cancer Res 60:1426~1433
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