지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.90 No.6
- 발행연도
- 2016.5
- 수록면
- 340 - 345 (6page)
이용수
초록· 키워드
오류제보하기
Purpose: To determine the prevalence of thrombophilia in Korean patients with an arterial thromboembolism (ATE) or a venous thromboembolism (VTE), and to evaluate the characteristic of VTE in patients with thrombophilia.
Methods: Hospital records of 294 patients (228 with VTE, 66 with ATE) including two foreign ones (mean age, 51.4 years) who underwent thrombophilia testing between August 2006 and March 2015 were reviewed retrospectively. In general, such screening was performed according to the guidelines of the international consensus statement for VTE. Thrombophilia testing included evaluations of the factor V Leiden and prothrombin G20210A mutations, levels of proteins C and S and antithrombin, and antiphospholipid antibody syndrome (APLS).
Results: A factor V Leiden mutation was not found in the 292 Korean patients. A prothrombin G21210A mutation was investigated in 33 patients but none was found. Among 226 Korean patients with VTE, 130 demonstrated no thrombophilia and 55 patients did after exclusion of 41 patients without confirmatory test. The most common form was protein S deficiency (31 of 55, 56%) followed by protein C deficiency, antithrombin deficiency, and APLS. When comparing patients with a VTE or deep vein thrombosis (DVT) according to the presence of thrombophilia, thrombophilia was associated with younger age (P = 0.001 for VTE; P < 0.001 for DVT) and a family history (P < 0.001 for VTE and DVT).
Conclusion: We did not find any factor V Leiden mutation in Korean subjects at high risk for thrombophilia. Therefore, this testing is not warranted. Thrombophilia was associated with VTE in younger age and a family history.
Methods: Hospital records of 294 patients (228 with VTE, 66 with ATE) including two foreign ones (mean age, 51.4 years) who underwent thrombophilia testing between August 2006 and March 2015 were reviewed retrospectively. In general, such screening was performed according to the guidelines of the international consensus statement for VTE. Thrombophilia testing included evaluations of the factor V Leiden and prothrombin G20210A mutations, levels of proteins C and S and antithrombin, and antiphospholipid antibody syndrome (APLS).
Results: A factor V Leiden mutation was not found in the 292 Korean patients. A prothrombin G21210A mutation was investigated in 33 patients but none was found. Among 226 Korean patients with VTE, 130 demonstrated no thrombophilia and 55 patients did after exclusion of 41 patients without confirmatory test. The most common form was protein S deficiency (31 of 55, 56%) followed by protein C deficiency, antithrombin deficiency, and APLS. When comparing patients with a VTE or deep vein thrombosis (DVT) according to the presence of thrombophilia, thrombophilia was associated with younger age (P = 0.001 for VTE; P < 0.001 for DVT) and a family history (P < 0.001 for VTE and DVT).
Conclusion: We did not find any factor V Leiden mutation in Korean subjects at high risk for thrombophilia. Therefore, this testing is not warranted. Thrombophilia was associated with VTE in younger age and a family history.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
[학술지(정기간행물)] - European Genetics Foundation. / 2005 / Thrombophilia and ve nous thromboembolism. International con sen sus statement. Guidelines according to scientific evidence / Int Angiol 24 : 1 ~ 26
[학술지(정기간행물)] - Shen MC. / 1997 / High prevalence of antithrombin III, protein C and protein S deficiency, but no factor V Leiden mutation in venous thrombophilic Chinese patients in Taiwan / Thromb Res 87 : 377 ~ 385
[학술지(정기간행물)] - Zama T. / 1996 / Low prevalence of activated protein C resistance and coagulation factor V Arg506 to Gln mutation among Japanese patients with various forms of thrombosis, and normal individuals / Int J Hematol 65 : 71 ~ 78
[학술지(정기간행물)] - Kim TW. / 1998 / Low prevalence of activated protein C resistance and coa gulation factor V Arg506 to Gln muta tion among Korean patients with deep vein thrombosis / J Korean Med Sci 13 : 587 ~ 590
[학술지(정기간행물)] - Kim HJ. / 2014 / Distinct frequencies and mutation spectrums of genetic throm bophilia in Korea in comparison with other Asian countries both in patients with thromboembolism and in the general population / Haematologica 99 : 561 ~ 569
[학술지(정기간행물)] - Shen MC. / 1997 / High prevalence of antithrombin III, protein C and protein S deficiency, but no factor V Leiden mutation in venous thrombophilic Chinese patients in Taiwan / Thromb Res 87 : 377 ~ 385
[학술지(정기간행물)] - Zama T. / 1996 / Low prevalence of activated protein C resistance and coagulation factor V Arg506 to Gln mutation among Japanese patients with various forms of thrombosis, and normal individuals / Int J Hematol 65 : 71 ~ 78
[학술지(정기간행물)] - Kim TW. / 1998 / Low prevalence of activated protein C resistance and coa gulation factor V Arg506 to Gln muta tion among Korean patients with deep vein thrombosis / J Korean Med Sci 13 : 587 ~ 590
[학술지(정기간행물)] - Kim HJ. / 2014 / Distinct frequencies and mutation spectrums of genetic throm bophilia in Korea in comparison with other Asian countries both in patients with thromboembolism and in the general population / Haematologica 99 : 561 ~ 569
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UCI(KEPA) : I410-ECN-0101-2017-514-001019549