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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 312 - 321 (10page)
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Purpose The risk factors for venous thromboembolism (VTE) in diffuse large B-cell lymphoma (DLBCL) are not clear although thrombosis can be associated with host status, tumor burden, and inflammatory activity. We assessed the effect of those factors on VTE in a cross-sectional study of patients enrolled in a prospective cohort study.
Materials and Methods We analyzed the occurrence of VTE in 322 patients with newly diagnosed DLBCL who received rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) between 2008 and 2011. Serum levels of inflammatory cytokines were measured from serum samples archived at diagnosis.
Results With a median follow-up duration of 41.9 months, VTE was documented in 34 patients (10.6%). A comparison of baseline characteristics indicated the group with VTE had higher percentage of old age, stage III/IV and extranodal involvements than the group without VTE (p < 0.05). Thus, the International Prognostic Index was significantly associated with VTE, but the Khorana score was not. A univariate competing risk factor analysis for VTE revealed that increased levels of inflammatory cytokines such as interleukin (IL)-6 and IL-10 were also associated with VTE (p < 0.05) in addition to host and tumor burden. However, a mul- tivariate analysis showed that two host factors including age (! 60 years) and poor perform- ance were independent risk factors for VTE.
Conclusion Among potential risk factors for VTE including tumor burden and inflammatory activity, age and performance status had a strong impact on the occurrence of VTE in patients with DLBCL who received R-CHOP.
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참고문헌 (24)
참고문헌 신청
Lekovic D / 2010 / Increased risk of venous thromboembolism in patients with primary mediastinal large B-cell lymphoma / Thromb Res 126:477~480
Caruso V / 2010 / Thrombotic complications in adult patients with lymphoma : a meta-analysis of 29 independent cohorts including 18 018 patients and 1149 events / Blood 115:5322~5328
허주령 / 2012 / Epidemiologic overview of malignant lymphoma / Blood Research 47(2):92~104
Coiffier B / 2005 / State-of-the-art therapeutics : diffuse large B-cell lymphoma / J Clin Oncol 23:6387~6393
Coiffier B / 2002 / CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma / N Engl J Med 346:235~242
Caruso V / 2010 / Thrombotic complications in adult patients with lymphoma : a meta-analysis of 29 independent cohorts including 18 018 patients and 1149 events / Blood 115:5322~5328
허주령 / 2012 / Epidemiologic overview of malignant lymphoma / Blood Research 47(2):92~104
Coiffier B / 2005 / State-of-the-art therapeutics : diffuse large B-cell lymphoma / J Clin Oncol 23:6387~6393
Coiffier B / 2002 / CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma / N Engl J Med 346:235~242
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