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자료유형
학술저널
저자정보
윤석윤 (순천향대학교) 이민영 (순천향대학교) 윤진아 (순천향대학교) 김한조 (순천향대학교) 김경하 (순천향대학교) 김세형 (순천향대학교) 이상철 (순천향대학교) 배상병 (순천향대학교) 김찬규 (순천향대학교) 이남수 (순천향대학교) 이규택 (순천향대학교) 박성규 (순천향대학교) 홍대식 (순천향대학교) 원종호 (순천향대학교)
저널정보
대한혈액학회 Blood Research Blood Research Vol.53 No.3
발행연도
2018.1
수록면
227 - 232 (6page)

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Background Pancreatic cancer is among the most common malignancies associated with venous thromboembolism (VTE). Asian patients are known to have a lower incidence of VTE com-pared to Caucasian patients. However, few studies have investigated the incidence of VTE in Asian patients with pancreatic cancer. Methods This retrospective review of medical records was performed on 505 patients with histo-pathologically proven advanced stage pancreatic cancer, from January 2006 to December 2012, at Soonchunhyang University Hospitals. Results Ninety-four patients (18.6%) had at least one pulmonary embolism (PE), deep vein throm-bosis (DVT), or splanchnic vein thrombosis (SVT); 38 patients had isolated SVT; and 56 patients (11.1%) had at least one classic VTE (PE and/or DVT of lower extremities). Patients with more advanced stages of pancreatic cancer (distant metastatic stage, recurrence) or who had received chemotherapy had a higher incidence of classic VTE. Patients who were simultaneously diagnosed with pancreatic cancer and classic VTE had a poorer prog-nosis than patients with subsequent VTEs. There was a significant difference in overall survival (OS) between the presence and absence of a concurrent classic VTE diagnosis (median: OS, 2.1 mo vs. 10.7 mo; P<0.001). Even when VTE included SVT, the result was similar (P<0.001). ConclusionIn In Korean patients with advanced pancreatic cancer, the incidence of VTEs is comparable to that of Caucasian patients. We also found that pancreatic cancer patients with con-current VTEs had a poor prognosis compared to patients who developed VTEs later.

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