지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 345 - 351 (7page)
이용수
초록· 키워드
오류제보하기
Propolis is a resinous material collected by honeybees from several plant sources. This research aimed at showing its protective effect against UVA-induced apoptosis of human keratinocyte HaCaT cells. Using Hoechst staining, it was demonstrated that propolis (5 and 10 μg/mL) significantly inhibited the apoptosis of HaCaT cells induced by UVA-irradiation. Propolis also showed the protective effect against loss of mitochondrial membrane potential induced by UVA-irradiaiton in HaCaT cells. Propolis also inhibited the expression of activated caspase-3 induced by UVA-irradiation. To investigate the role of ROS in UVA-induced apoptosis and protection by propolis, the generation of ROS was determined in cells. The results showed that the generation of ROS was markedly reduced in cells pretreated with propolis. Consequently, propolis protected human keratinocyte HaCaT cells against UVA-induced apoptosis, which might be related to the reduction of ROS generation by UVA-irradiation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (50)
참고문헌 신청
Aragane, Y / 1998 / UV light induces apoptosis via direct activation of CD95 (Fas/APO- 1) independently of it’s ligand CD95L / J. Cell Biol 140:171~182
Danno, K / 1987 / Sunburn cell: factors involved in its formation. Photochem / Photobiol 45:683~690
Ziegler, A / 1994 / Sunburn and p53 in the onset of skin cancer / Nature 372:773~776
Fuchs, J / 1991 / Photooxidative Stress in the Skin in Oxidative Stress: Oxidants and Antioxidants / Academic Press :559~583
Heck, D. E / 2004 / Solar ultraviolet radiation as a trigger of cell signal transduction / Toxicol. Appl. Pharmacol 195:288~297
Danno, K / 1987 / Sunburn cell: factors involved in its formation. Photochem / Photobiol 45:683~690
Ziegler, A / 1994 / Sunburn and p53 in the onset of skin cancer / Nature 372:773~776
Fuchs, J / 1991 / Photooxidative Stress in the Skin in Oxidative Stress: Oxidants and Antioxidants / Academic Press :559~583
Heck, D. E / 2004 / Solar ultraviolet radiation as a trigger of cell signal transduction / Toxicol. Appl. Pharmacol 195:288~297
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UCI(KEPA) : I410-ECN-0101-2017-513-001339618