지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
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Geranium thunbergii is a perennial plant commonly used as an oriental medicine for prevention of diarrhea, constipation, and gastrointestinal disorders. However, its anti-inflammatory effect has not been evaluated thus far. Therefore, the present study aimed to investigate the anti-inflammatory effect of G. thunbergii. In this study, G. thunbergii extracted with methanol; this methanol extract was further partitioned using various solvents, and G. thunbergii ethyl acetate fraction (GTEF) was obtained. To determine the anti-inflammatory activity of G. thunbergii, the effects of GTEF on nitric oxide (NO) production in lipopolysaccharide-stimulated RAW 264.7 cells were evaluated. GTEF suppressed NO production in a dose-dependent manner without any toxic effects. In addition, western blotting was performed to examine the effect of GTEF on expression of inducible nitric oxide synthase and cyclooxygenase-2. These results suggest that GTEF as a phytoextract may be useful for the prevention or treatment of inflammation.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
References
참고문헌 (16)
참고문헌 신청
[학술지(정기간행물)] - Yang Y / 2012 / In vitro and in vivo antiinflammatory activities of Polygonum hydropiper methanol extract / J. Ethnopharmacol 139 : 616 ~ 625
[학술지(정기간행물)] - Kim EO / 2012 / Anti-inflammatory activity of hydroxycinnamic acid derivatives isolated from corn bran in lipopolysaccharide-stimulated RAW 264.7 macrophage / Food Chem. Toxicol 50 : 1309 ~ 1316
[학술지(정기간행물)] - Yu T / 2011 / Anti-inflammatory activity of Sorbus commixta water extract and its molecular inhibitory mechanism / J. Ethnopharmacol 134 : 493 ~ 500
[학술지(정기간행물)] - Bharat Reddy D / 2009 / Chebulagic acid (CA) attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophage / Biochem. Bioph. Res. Com 381 : 112 ~ 117
[학술지(정기간행물)] - Park YM / 2005 / In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus / J. Ethnopharmacol 101 : 120 ~ 128
[학술지(정기간행물)] - Kim EO / 2012 / Anti-inflammatory activity of hydroxycinnamic acid derivatives isolated from corn bran in lipopolysaccharide-stimulated RAW 264.7 macrophage / Food Chem. Toxicol 50 : 1309 ~ 1316
[학술지(정기간행물)] - Yu T / 2011 / Anti-inflammatory activity of Sorbus commixta water extract and its molecular inhibitory mechanism / J. Ethnopharmacol 134 : 493 ~ 500
[학술지(정기간행물)] - Bharat Reddy D / 2009 / Chebulagic acid (CA) attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophage / Biochem. Bioph. Res. Com 381 : 112 ~ 117
[학술지(정기간행물)] - Park YM / 2005 / In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus / J. Ethnopharmacol 101 : 120 ~ 128
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UCI(KEPA) : I410-ECN-0101-2017-594-001870639