지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 49 - 54 (6page)
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초록· 키워드
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Vitamin D3 is a fat-soluble secosteroid responsible for enhancing intestinal absorption of calcium, iron, and other materials. Vitamin D3 deficiency, therefore, can cause health problems such as metabolic diseases, and bone disorder. Female sex hormones including estrogen and progesterone are biosynthesized mainly in the granulosa cells of ovary. In this study, we isolated granulosa cells from porcine ovary and cultured for the experiments. In order to examine the effect of vitamin D3 on the ovarian granulosa cells, the mRNA and protein levels of genes were analyzed by real-time PCR and Western blot assay. The production of estrogen from the granulosa cells was also measured by the ELISA assay. Genes associated with follicle growth were not significantly altered by vitamin D3. However, it increases expression of genes involved in the estrogen-biosynthesis. Further, estrogen concentrations in porcine granulosa cell-cultured media increased in response to vitamin D3. These results showed that vitamin D3 is a powerful regulator of sex steroid hormone production in porcine granulosa cells, suggesting that vitamin D deficiency may result in inappropriate sexual development of industrial animals and eventually economic loss.
목차
INTRODUCTION
MATERIAL AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
Holick, M.F / 1994 / McCollum Award Lecture, 1994: vitamin D--new horizons for the 21st century / Am. J. Clin. Nutr 60:619~630
Bell, T.D / 2010 / The biology and pathology of vitamin D control in bone / J. Cell. Biochem 111:7~13
Hollis, B.W / 1996 / Assessment of vitamin D nutritional and hormonal status: what to measure and how to do it / Calcif. Tissue Int 58:4~5
DeLuca, H.M / 1971 / Isolation and identification of 1, 25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine / Biochemistry 10:2799~2804
DeLuca, H.F / 2004 / Overview of general physiologic features and functions of vitamin D / Am. J. Clin. Nutr 80:1689S~1696S
Bell, T.D / 2010 / The biology and pathology of vitamin D control in bone / J. Cell. Biochem 111:7~13
Hollis, B.W / 1996 / Assessment of vitamin D nutritional and hormonal status: what to measure and how to do it / Calcif. Tissue Int 58:4~5
DeLuca, H.M / 1971 / Isolation and identification of 1, 25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine / Biochemistry 10:2799~2804
DeLuca, H.F / 2004 / Overview of general physiologic features and functions of vitamin D / Am. J. Clin. Nutr 80:1689S~1696S
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UCI(KEPA) : I410-ECN-0101-2017-513-002054387