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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.92 No.1
- 발행연도
- 2017.1
- 수록면
- 1 - 8 (8page)
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Purpose: The measurement of serum thyroglobulin (Tg) of papillary thyroid carcinoma patients, 12 months after total thyroidectomy and radioactive iodine (RAI) ablation following thyroxine hormone withdrawal (T4-off Tg) or recombinant human thyroid-stimulating hormone stimulation (rhTSH-Tg), is standard method for monitoring disease status. The aim of this study was to find predictive factors for detectable T4-off Tg during follow-up.
Methods: A retrospective review was conducted of 329 patients who underwent total thyroidectomy and RAI ablation between October 2008 and August 2012. Subjects were assigned to high (>1 ng/mL, n = 53) and low (≤1 ng/mL, n = 276)groups, based on T4-off Tg measured 12 months postoperatively. Demographic and clinicopathological characteristics at diagnosis and follow-up were compared between the 2 groups.
Results: The low and high T4-off Tg groups differed with respect to tumor size, preoperative Tg, ablative Tg, cervical lymph node metastasis, thyroglobulinemia out of proportion to results of diagnostic whole body scan, and American Thyroid Association 3-level stratification and restratification. Multivariate analysis confirmed that ablative Tg > 1.0 ng/mL (odds ratio [OR], 10.801; P = 0.001), more than 5 cervical lymph node metastasis (OR, 6.491; P = 0.003), and thyroglobulinemia out of proportion (OR, 9.221; P = 0.000) were risk factors.
Conclusion: Ablative Tg >1.0 ng/mL, more than 5 cervical lymph node metastasis, and thyroglobulinemia out of proportion were independent factors for T4-off Tg >1 ng/mL 12 months postoperative. In low-risk patients without these risk factors, the possible omission of Tg measurements could be considered during follow-up.
Methods: A retrospective review was conducted of 329 patients who underwent total thyroidectomy and RAI ablation between October 2008 and August 2012. Subjects were assigned to high (>1 ng/mL, n = 53) and low (≤1 ng/mL, n = 276)groups, based on T4-off Tg measured 12 months postoperatively. Demographic and clinicopathological characteristics at diagnosis and follow-up were compared between the 2 groups.
Results: The low and high T4-off Tg groups differed with respect to tumor size, preoperative Tg, ablative Tg, cervical lymph node metastasis, thyroglobulinemia out of proportion to results of diagnostic whole body scan, and American Thyroid Association 3-level stratification and restratification. Multivariate analysis confirmed that ablative Tg > 1.0 ng/mL (odds ratio [OR], 10.801; P = 0.001), more than 5 cervical lymph node metastasis (OR, 6.491; P = 0.003), and thyroglobulinemia out of proportion (OR, 9.221; P = 0.000) were risk factors.
Conclusion: Ablative Tg >1.0 ng/mL, more than 5 cervical lymph node metastasis, and thyroglobulinemia out of proportion were independent factors for T4-off Tg >1 ng/mL 12 months postoperative. In low-risk patients without these risk factors, the possible omission of Tg measurements could be considered during follow-up.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
[학술지(정기간행물)] - Links TP / 2005 / Life expectancy in differentiated thyroid cancer : a novel approach to survival analysis / Endocr Relat Cancer 12 : 273 ~ 280
[학술지(정기간행물)] - 최윤미 / 2014 / Standardized Thyroid Cancer Mortality in Korea between 1985 and 2010 / Endocrinology and Metabolism 29 (4) : 530 ~ 535
[학술지(정기간행물)] - 정규원 / 2014 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2011 / Cancer Research and Treatment 46 (2) : 109 ~ 123
[인터넷자원] - National Cancer Institute. / / SEER Cancer Statistics Review, 1975-2011
[학술지(정기간행물)] - American Thyroid Association (ATA)Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer / 2009 / Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer / Thyroid 19 : 1167 ~ 1214
[학술지(정기간행물)] - 최윤미 / 2014 / Standardized Thyroid Cancer Mortality in Korea between 1985 and 2010 / Endocrinology and Metabolism 29 (4) : 530 ~ 535
[학술지(정기간행물)] - 정규원 / 2014 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2011 / Cancer Research and Treatment 46 (2) : 109 ~ 123
[인터넷자원] - National Cancer Institute. / / SEER Cancer Statistics Review, 1975-2011
[학술지(정기간행물)] - American Thyroid Association (ATA)Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer / 2009 / Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer / Thyroid 19 : 1167 ~ 1214
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UCI(KEPA) : I410-ECN-0101-2017-514-001991735