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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Health and Toxicology Vol.31
- 발행연도
- 2016.12
- 수록면
- 53 - 57 (5page)
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초록· 키워드
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Objectives There have been developed to use targeting ability for antimicrobial, anticancerous, gene therapy and cosmetics through analysis of various membrane proteins isolated from cell organelles.
Methods It was examined about the lysosomal membrane protein extracted from lysosome isolated from HeLa cell treated by 100 ppm melanin for 24 hours in order to find associated with targeting ability to melanin using by 2-dimensional electrophoresis.
Results The result showed 14 up-regulated (1.5-fold) and 13 down-regulated (2.0-fold) spots in relation to melanin exposure.
Conclusions It has been found that lysosomal membrane proteins are associated with melanin to decolorize and quantity through cellular activation of lysosome.
Methods It was examined about the lysosomal membrane protein extracted from lysosome isolated from HeLa cell treated by 100 ppm melanin for 24 hours in order to find associated with targeting ability to melanin using by 2-dimensional electrophoresis.
Results The result showed 14 up-regulated (1.5-fold) and 13 down-regulated (2.0-fold) spots in relation to melanin exposure.
Conclusions It has been found that lysosomal membrane proteins are associated with melanin to decolorize and quantity through cellular activation of lysosome.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (14)
참고문헌 신청
Kricker A / 1994 / Sun exposure and non-melanocytic skin cancer / Cancer Causes Control 5(4):367~392
Halaban R / 1983 / Regulation of tyrosinase in human melanocytes grown in culture / J Cell Biol 97(2):480~488
Borges CR / 2001 / Relationship of melanin degradation products to actual melanin content: application to human hair / Anal Biochem 290(1):116~125
Butler MJ / 2005 / Degradation of melanin or inhibition of its synthesis: are these a significant approach as a biological control of phytopathogenic fungi? / Biol Control 32(2):326~336
No JK / 1999 / Inhibition of tyrosinase by green tea components / Life Sci 65(21):PL241~PL246
Halaban R / 1983 / Regulation of tyrosinase in human melanocytes grown in culture / J Cell Biol 97(2):480~488
Borges CR / 2001 / Relationship of melanin degradation products to actual melanin content: application to human hair / Anal Biochem 290(1):116~125
Butler MJ / 2005 / Degradation of melanin or inhibition of its synthesis: are these a significant approach as a biological control of phytopathogenic fungi? / Biol Control 32(2):326~336
No JK / 1999 / Inhibition of tyrosinase by green tea components / Life Sci 65(21):PL241~PL246
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UCI(KEPA) : I410-ECN-0101-2017-539-002198415