지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Health and Toxicology Vol.31
- 발행연도
- 2016.12
- 수록면
- 88 - 96 (9page)
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초록· 키워드
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Objectives Banha-sasim-tang (BST), which consists of seven different herbs, is one of the most popular herbal formulae for treating gastrointestinal disorders in Eastern Asia. The commonly used herbal medicine is often co-administered with other therapeutic drugs, which raises the possibility of herb–drug interactions and may modify the clinical safety profile of therapeutic drugs.
Methods We investigated the potential herb–drug interactions between BST extract and midazolam (MDZ) in mice. The area under the plasma concentration-time curve (AUC) of MDZ and 1ʹ-hydroxymidazolam (1ʹ-OH-MDZ) was evaluated for both oral and intraperitoneal administration of MDZ, following oral administration of BST (0.5 and 1 g/kg).
Results It was found that the AUC of MDZ and 1ʹ-OH-MDZ was lower in case of oral administration of MDZ. Administration of BST extract was not associated with hepatic cytochrome P450 activity. BST extract induced a strong reduction in pH and it has been reported that oral mucosal absorption of MDZ is lower at low pH. The decreased absorption rate of MDZ might be caused by the ingredients of BST and may not be related to other factors such as increased excretion of MDZ by P-glycoprotein.
Conclusions The altered pharmacokinetics of midazolam caused by co-administration with BST in vivo could be attributed to a decrease in pH and subsequent reduction of MDZ absorption rate.
Methods We investigated the potential herb–drug interactions between BST extract and midazolam (MDZ) in mice. The area under the plasma concentration-time curve (AUC) of MDZ and 1ʹ-hydroxymidazolam (1ʹ-OH-MDZ) was evaluated for both oral and intraperitoneal administration of MDZ, following oral administration of BST (0.5 and 1 g/kg).
Results It was found that the AUC of MDZ and 1ʹ-OH-MDZ was lower in case of oral administration of MDZ. Administration of BST extract was not associated with hepatic cytochrome P450 activity. BST extract induced a strong reduction in pH and it has been reported that oral mucosal absorption of MDZ is lower at low pH. The decreased absorption rate of MDZ might be caused by the ingredients of BST and may not be related to other factors such as increased excretion of MDZ by P-glycoprotein.
Conclusions The altered pharmacokinetics of midazolam caused by co-administration with BST in vivo could be attributed to a decrease in pH and subsequent reduction of MDZ absorption rate.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (15)
참고문헌 신청
Chen XW / 2012 / Herb-drug interactions and mechanistic and clinical considerations / Curr Drug Metab 13(5):640~651
Wacher VJ / 1995 / Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein:implications for drug delivery and activity in cancer chemotherapy / Mol Carcinog 13(3):129~134
Nordt SP / 1997 / Midazolam: a review of therapeutic uses and toxicity / J Emerg Med 15(3):357~365
Perloff MD / 2000 / Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms / J Pharmacol Exp Ther 292(2):618~628
Kronbach T / 1989 / Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4 / Mol Pharmacol 36(1):89~96
Wacher VJ / 1995 / Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein:implications for drug delivery and activity in cancer chemotherapy / Mol Carcinog 13(3):129~134
Nordt SP / 1997 / Midazolam: a review of therapeutic uses and toxicity / J Emerg Med 15(3):357~365
Perloff MD / 2000 / Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms / J Pharmacol Exp Ther 292(2):618~628
Kronbach T / 1989 / Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4 / Mol Pharmacol 36(1):89~96
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UCI(KEPA) : I410-ECN-0101-2017-539-002198344