지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.3
- 수록면
- 34 - 45 (12page)
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Objectives: This study aimed to investigate the effect of banhasasim-tang intravenous herbal acupuncture (BST-IVHA) on emesis induced by chemotherapy in rats.
Methods: This study used methotrexate(MTX)-induced Rat-Pica model. The rats were randomly allocated into seven groups; normal group, two saline groups, four Banhasasim-tang(BST) groups (groups treated with BST-IVHA). All the experimental animals except those in the normal group were injected with MTX. Those in the pre-treatment groups were treated with saline injection (saline group) or BST-IVHA (BST group) before MTX injection. Those in the post-treatment groups were treated with saline injection or BST-IVHA after MTX injection. Two different dosages of BST-IVHA solution (low dose; BST-1 group, high dose; BST-2 group) were used. The changes in body weight, food intake, and kaolin consumption at 24h, 48h, and 60h were monitored and analyzed.
Results: 1. No significant change was found in body weight. 2. The food intake at 48h was increased significantly in the BST-1 pre-treatment group(19.89±0.01g) compared to the pre-saline group(18.68±0.26g). 3. The kaolin consumption was significantly decreased in the BST-1 pre-treatment group at 24h(0.24±0.02g) and 60h(0.36±0.14g), in the BST-2 pre-treatment group at 48h(0.02±0.01g) and 60h(0.80±0.31g) compared to the pre-saline group(24h:0.81±0.37g, 48h:0.76±0.43g, 60h:1.56±0.03g). The kaolin consumption was also significantly decreased in
the in the BST-1 post-treatment group at 24h(0.05±0.02g), 48h(0.64±0.06g) and 60h(0.14±0.05g), in the BST-2 post-treatment group at 48h(0.01±0.01g) and 60h(0.01±0.01g) compared to the post-saline group(24h:0.51±0.4g, 48h:3.58±0.33g, 60h:2.5±0.2g).
Conclusions: BST-IVHA showed an anti-emetic effect in MTX-induced rat-pica model. This result suggests that BST-IVHA could be an effective treatment for chemotherapy-induced emesis.
Methods: This study used methotrexate(MTX)-induced Rat-Pica model. The rats were randomly allocated into seven groups; normal group, two saline groups, four Banhasasim-tang(BST) groups (groups treated with BST-IVHA). All the experimental animals except those in the normal group were injected with MTX. Those in the pre-treatment groups were treated with saline injection (saline group) or BST-IVHA (BST group) before MTX injection. Those in the post-treatment groups were treated with saline injection or BST-IVHA after MTX injection. Two different dosages of BST-IVHA solution (low dose; BST-1 group, high dose; BST-2 group) were used. The changes in body weight, food intake, and kaolin consumption at 24h, 48h, and 60h were monitored and analyzed.
Results: 1. No significant change was found in body weight. 2. The food intake at 48h was increased significantly in the BST-1 pre-treatment group(19.89±0.01g) compared to the pre-saline group(18.68±0.26g). 3. The kaolin consumption was significantly decreased in the BST-1 pre-treatment group at 24h(0.24±0.02g) and 60h(0.36±0.14g), in the BST-2 pre-treatment group at 48h(0.02±0.01g) and 60h(0.80±0.31g) compared to the pre-saline group(24h:0.81±0.37g, 48h:0.76±0.43g, 60h:1.56±0.03g). The kaolin consumption was also significantly decreased in
the in the BST-1 post-treatment group at 24h(0.05±0.02g), 48h(0.64±0.06g) and 60h(0.14±0.05g), in the BST-2 post-treatment group at 48h(0.01±0.01g) and 60h(0.01±0.01g) compared to the post-saline group(24h:0.51±0.4g, 48h:3.58±0.33g, 60h:2.5±0.2g).
Conclusions: BST-IVHA showed an anti-emetic effect in MTX-induced rat-pica model. This result suggests that BST-IVHA could be an effective treatment for chemotherapy-induced emesis.
목차
서론
재료와 방법
결과
고찰
결론
참고문헌
참고문헌 (36)
참고문헌 신청
Park JG, Park CI, Kim NK. Oncology. 1st ed. Seoul:Ilchokak. 2009:3, 128.
Graham KM, Pecoraro DA, Ventura M, Meyer CC. Reducing the incidence of stomatitis using a quality assessment and improvement approach. Cancer Nurs. 1993;16(2:117-22.
Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, et al. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 2004;100(9): 1995-2025.
Hockenberry-eaton M, Benner A. Patterns of nausea and vomiting in children: nursing assessment and intervention. Oncol Nurs Forum. 1990;17(4):575-84.
Kim HJ, Kim HS. Nausea/Vomiting and Self -care in patients with Cancer on Chemotherapy. J Korean Acad Funda Nurs. 2005;12(2:180-5.
Graham KM, Pecoraro DA, Ventura M, Meyer CC. Reducing the incidence of stomatitis using a quality assessment and improvement approach. Cancer Nurs. 1993;16(2:117-22.
Sonis ST, Elting LS, Keefe D, Peterson DE, Schubert M, Hauer-Jensen M, et al. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 2004;100(9): 1995-2025.
Hockenberry-eaton M, Benner A. Patterns of nausea and vomiting in children: nursing assessment and intervention. Oncol Nurs Forum. 1990;17(4):575-84.
Kim HJ, Kim HS. Nausea/Vomiting and Self -care in patients with Cancer on Chemotherapy. J Korean Acad Funda Nurs. 2005;12(2:180-5.
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UCI(KEPA) : I410-ECN-0101-2017-519-002365061