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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 152 - 162 (11page)
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초록· 키워드
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End-stage renal disease (ESRD) with immune disorder involves complex interactions between the innate and adaptive immune responses. ESRD is associated with various alterations in immune function such as a reduction in polymorphonuclear leukocyte bactericidal activity, a suppression of lymphocyte proliferative response to stimuli, and a malfunction of cell-mediated immunity at the molecular level. ESRD also increases patients’ propensity for infections and malignancies as well as causing a diminished response to vaccination. Several factors influence the immunodeficiency in patients with ESRD, including uremic toxins, malnutrition, chronic inflammation, and the therapeutic dialysis modality. The alteration of T-cell function in ESRD has been considered to be a major factor underlying the impaired adaptive cellular immunity in these patients. However, cumulative evidence has suggested that the immune defect in ESRD can be caused by an Ag-presenting dendritic cell (DC) dysfunction in addition to a T-cell defect. It has been reported that ESRD has a deleterious effect on DCs both in terms of their number and function, although the precise mechanism by which DC function becomes altered in these patients is unclear. In this review, we discuss the effects of ESRD on the number and function of DCs and propose a possible molecular mechanism for DC dysfunction. We also address therapeutic approaches to improve immune function by optimally activating DCs in patients with ESRD.
목차
INTRODUCTION
SOURCES AND FUNCTIONS OF DCs
ABNORMALITIES OF DCs IN PATIENTS WITH ESRD
MODULATION OF DC FUNCTION IN PATIENTS WITH ESRD
CONCLUSIONS
REFERENCES
참고문헌 (89)
참고문헌 신청
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Anding, K., P. Gross, J. M. Rost, D. Allgaier, and E. Jacobs. 2003. The influence of uraemia and haemodialysis on neutrophil phagocytosis and antimicrobial killing. Nephrol. Dial. Transplant. 18: 2067-2073.
Verkade, M. A., J. van de Wetering, N. Klepper, L. M. Vaessen, W. Weimar, and M. G. Betjes. 2004. Peripheral blood dendritic cells and GM-CSF as an adjuvant for hepatitis B vaccination in hemodialysis patients. Kidney Int. 66: 614-621.
Sester, M., U. Sester, P. Clauer, G. Heine, U. Mack, T. Moll, G. W. Sybrecht, A. Lalvani, and H. Kohler. 2004. Tuberculin skin testing underestimates a high prevalence of latent tuberculosis infection in hemodialysis patients. Kidney Int. 65: 1826-1834.
Yoon, J. W., S. Gollapudi, M. V. Pahl, and N. D. Vaziri. 2006. Naive and central memory T-cell lymphopenia in end-stage renal disease. Kidney Int. 70: 371-376.
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UCI(KEPA) : I410-ECN-0101-2018-517-000885528