지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 122 - 131 (10page)
이용수
초록· 키워드
오류제보하기
Autophagy is a self-degradative process that removes misfolded or aggregated proteins, clears damaged organelles, as well as eliminates intracellular pathogens playing a role in innate immunity. Mycobacterium abscessus (M. abscessus) has been reported as a causative organism in nearly 80% of the rapid growing mycobacteria (RGM) pulmonary disease. The strain exhibits two different colony types: the smooth (S) one which is considered wild-type and the rough (R) one which is the mutated strain. In accordance to the colony morphology, the S and R types display varying autophagic responses in the host cells with the R type inducing elevated autophagy compared to the S type. The major difference in the autophagy could be based on the bioactive molecules exposed on the surface of the S and R types. Though autophagy has a vital role to play in the clearance of intracellular pathogens, very little is known on the autophagy induced by M. abscessus. It has been known that the intracellular pathogens employ different strategies to evade the autophagic pathway and to survive within the host cells. This review summarizes the most up-to-date findings on autophagy induced by M. abscessus morphotypes and how M. abscessus evades the autophagic machinery to divide and thrive inside the host cells. In addition, the prospects of autophagic machinery in devising new anti-infective strategies against mycobacterial infection is also been discussed.
목차
I. INTRODUCTION
II. CELLULAR AND MOLECULARMECHANISMS OF AUTOPHAGY
III. AUTOPHAGY IN INFECTION AND IMMUNITY
IV. AUTOPHAGY INDUCTION BY M. ABSCESSUS
V. CONCLUSION
REFERENCES
참고문헌 (89)
참고문헌 신청
[학술지(정기간행물)] - Cuervo AM / 2004 / Autophagy: in sickness and in health / Trends Cell Biol 14 : 70 ~ 77
[학술지(정기간행물)] - Klionsky DJ / 2005 / The molecular machinery of autophagy: unanswered questions / J Cell Sci 118 : 7 ~ 18
[학술지(정기간행물)] - Levine B / 2004 / Development by self-digestion: molecular mechanisms and biological functions of autophagy / Dev Cell 6 : 463 ~ 477
[학술지(정기간행물)] - Mizushima N / 2007 / Protein turnover via autophagy: implications for metabolism / Annu Rev Nutr 27 : 19 ~ 40
[학술지(정기간행물)] - Shintani T / 2004 / Autophagy in health and disease: a double-edged sword / Science 306 : 990 ~ 995
[학술지(정기간행물)] - Klionsky DJ / 2005 / The molecular machinery of autophagy: unanswered questions / J Cell Sci 118 : 7 ~ 18
[학술지(정기간행물)] - Levine B / 2004 / Development by self-digestion: molecular mechanisms and biological functions of autophagy / Dev Cell 6 : 463 ~ 477
[학술지(정기간행물)] - Mizushima N / 2007 / Protein turnover via autophagy: implications for metabolism / Annu Rev Nutr 27 : 19 ~ 40
[학술지(정기간행물)] - Shintani T / 2004 / Autophagy in health and disease: a double-edged sword / Science 306 : 990 ~ 995
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UCI(KEPA) : I410-ECN-0101-2018-475-001319928