지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 334 - 343 (10page)
이용수
초록· 키워드
오류제보하기
Background: Progressed tissue culture techniques have allowed us to easily obtain mass products of tissue-cultured mountain ginseng over 100 yr old (TCMG-100). We investigated the effects of TCMG-100 extract on erectile function using in vitro and in vivo studies.
Methods: To examine the relaxation effects and mechanisms of action of TCMG-100 on rabbit cavernosal strips evaluated in an organ bath. To investigate the long-term treatment effect of TCMG-100, 8-wk administration was performed. After administration of TCMG-100, intracavernosal pressure, cyclic guanosine monophosphate and nitric oxide (NO) levels of cavernosal tissue, serum testosterone level, histological observation of collagen fiber, endothelium, smooth muscle cell, and transforming growth factor-β1 were investigated.
Results: TCMG-100 extract displayed dose-dependent relaxation effects on precontracted rabbit corporal smooth muscle. The TCMG-100-induced relaxation was significantly reduced by removing the endothelium, and treatment with an NO synthase inhibitor or NO scavenger. Eight weeks of TCMG-100 administration increased intracavernosal pressure in a rat model. The levels of cyclic guanosine monophosphate and NO in the corpus callosum and serum testosterone level were also increased by TCMG-100 treatment. Furthermore, histological evaluation of collagen, smooth muscle, and endothelium showed increases in endothelium and smooth muscle, and a decrease in transforming growth factor-β1 expression.
Conclusion: These relaxation effects on corporal smooth muscle and increased erectile function suggest that TCMG-100 might be used as an alternative herbal medicine to improve erectile function.
Methods: To examine the relaxation effects and mechanisms of action of TCMG-100 on rabbit cavernosal strips evaluated in an organ bath. To investigate the long-term treatment effect of TCMG-100, 8-wk administration was performed. After administration of TCMG-100, intracavernosal pressure, cyclic guanosine monophosphate and nitric oxide (NO) levels of cavernosal tissue, serum testosterone level, histological observation of collagen fiber, endothelium, smooth muscle cell, and transforming growth factor-β1 were investigated.
Results: TCMG-100 extract displayed dose-dependent relaxation effects on precontracted rabbit corporal smooth muscle. The TCMG-100-induced relaxation was significantly reduced by removing the endothelium, and treatment with an NO synthase inhibitor or NO scavenger. Eight weeks of TCMG-100 administration increased intracavernosal pressure in a rat model. The levels of cyclic guanosine monophosphate and NO in the corpus callosum and serum testosterone level were also increased by TCMG-100 treatment. Furthermore, histological evaluation of collagen, smooth muscle, and endothelium showed increases in endothelium and smooth muscle, and a decrease in transforming growth factor-β1 expression.
Conclusion: These relaxation effects on corporal smooth muscle and increased erectile function suggest that TCMG-100 might be used as an alternative herbal medicine to improve erectile function.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (35)
참고문헌 신청
[학술지(정기간행물)] - Feldman HA / 1994 / Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study / J Urol 151 : 54 ~ 61
[학술지(정기간행물)] - Seftel AD / 2004 / The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction / J Urol 171 : 2341 ~ 2345
[학술지(정기간행물)] - El-Latif MA / 2006 / Diagnostic value of nitric oxide, lipoprotein(a), and malondialdehyde levels in the peripheral venous and cavernous blood of diabetics with erectile dysfunction / Int J Impot Res 18 : 544 ~ 549
[학술지(정기간행물)] - Emarah AM / 2010 / Correlation between penile cavernosal artery blood flow and retinal vascular findings in arteriogenic erectile dysfunction / Clin Ophthalmol 4 : 1047 ~ 1051
[학술지(정기간행물)] - Kim SD / 2013 / Improvement of erectile function by Korean red ginseng (Panax ginseng) in a male rat model of metabolic syndrome / Asian J Androl 15 : 395 ~ 399
[학술지(정기간행물)] - Seftel AD / 2004 / The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction / J Urol 171 : 2341 ~ 2345
[학술지(정기간행물)] - El-Latif MA / 2006 / Diagnostic value of nitric oxide, lipoprotein(a), and malondialdehyde levels in the peripheral venous and cavernous blood of diabetics with erectile dysfunction / Int J Impot Res 18 : 544 ~ 549
[학술지(정기간행물)] - Emarah AM / 2010 / Correlation between penile cavernosal artery blood flow and retinal vascular findings in arteriogenic erectile dysfunction / Clin Ophthalmol 4 : 1047 ~ 1051
[학술지(정기간행물)] - Kim SD / 2013 / Improvement of erectile function by Korean red ginseng (Panax ginseng) in a male rat model of metabolic syndrome / Asian J Androl 15 : 395 ~ 399
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UCI(KEPA) : I410-ECN-0101-2018-524-001598456