지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 134 - 143 (10page)
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초록· 키워드
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Background: The prevalence of allergic inflammatory diseases such as atopic dermatitis (AD), asthma, and allergic rhinitis worldwide has increased and complete recovery is difficult. Korean Red Ginseng, which is the heat-processed root of Panax ginseng Meyer, is widely and frequently used as a traditional medicine in East Asia. In this study, we investigated whether Korean Red Ginseng water extract (RGE) regulates the expression of proinflammatory cytokines and chemokines via the mitogen-activated protein kinases (MAPKs)/nuclear factor kappa B (NF-kB) pathway in allergic inflammation.
Methods: Compound 48/80-induced anaphylactic shock and 1-fluoro-2,4-dinitrobenzene (DNFB)-induced AD-like skin lesion mice models were used to investigate the antiallergic effects of RGE. Human keratinocytes (HaCaT cells) and human mast cells (HMC-1) were also used to clarify the effects of RGE on the expression of proinflammatory cytokines and chemokines.
Results: Anaphylactic shock and DNFB-induced AD-like skin lesions were attenuated by RGE administration through reduction of serum immunoglobulin E (IgE) and interleukin (IL)-6 levels in mouse models. RGE also reduced the production of proinflammatory cytokines including IL-1β, IL-6, and IL-8, and expression of chemokines such as IL-8, thymus and activation-regulated chemokine (TARC), and macrophage-derived chemokine (MDC) in HaCaT cells. Additionally, RGE decreased the release of tumor necrosis factor-α (TNF-α), IL-1β, IL-6, and IL-8 as well as expressions of chemokines including macrophage inflammatory protein (MIP)-1α, MIP-1b, regulated on activation, normal T cell expressed and secreted (RANTES), monocyte chemoattractant protein (MCP)-1, and IL-8 in HMC-1 cells. Furthermore, our data demonstrated that these inhibitory effects occurred through blockage of the MAPK and NF-kB pathway.
Conclusion: RGE may be a useful therapeutic agent for the treatment of allergic inflammatory diseases such as AD-like dermatitis.
Methods: Compound 48/80-induced anaphylactic shock and 1-fluoro-2,4-dinitrobenzene (DNFB)-induced AD-like skin lesion mice models were used to investigate the antiallergic effects of RGE. Human keratinocytes (HaCaT cells) and human mast cells (HMC-1) were also used to clarify the effects of RGE on the expression of proinflammatory cytokines and chemokines.
Results: Anaphylactic shock and DNFB-induced AD-like skin lesions were attenuated by RGE administration through reduction of serum immunoglobulin E (IgE) and interleukin (IL)-6 levels in mouse models. RGE also reduced the production of proinflammatory cytokines including IL-1β, IL-6, and IL-8, and expression of chemokines such as IL-8, thymus and activation-regulated chemokine (TARC), and macrophage-derived chemokine (MDC) in HaCaT cells. Additionally, RGE decreased the release of tumor necrosis factor-α (TNF-α), IL-1β, IL-6, and IL-8 as well as expressions of chemokines including macrophage inflammatory protein (MIP)-1α, MIP-1b, regulated on activation, normal T cell expressed and secreted (RANTES), monocyte chemoattractant protein (MCP)-1, and IL-8 in HMC-1 cells. Furthermore, our data demonstrated that these inhibitory effects occurred through blockage of the MAPK and NF-kB pathway.
Conclusion: RGE may be a useful therapeutic agent for the treatment of allergic inflammatory diseases such as AD-like dermatitis.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (47)
참고문헌 신청
[학술지(정기간행물)] - Leung DYM / 2003 / Atopic dermatitis / Lancet 361 : 151 ~ 160
[학술지(정기간행물)] - Novak N / 2009 / New insights into the mechanism and management of allergic diseases : atopic dermatitis / Allergy 64 : 265 ~ 275
[학술지(정기간행물)] - Sebastiani S / 2002 / The role of chemokines in allergic contact dermatitis / Arch Dermatol Res 293 : 552 ~ 559
[학술지(정기간행물)] - Gröne A / 2002 / Keratinocytes and cytokines / Vet Immunol Immunopathol 88 : 1 ~ 12
[학술지(정기간행물)] - Uchi H / 2000 / Cytokines and chemokines in the epidermis / J Dermatol Sci 24 (Suppl. 1) : S29 ~ S38
[학술지(정기간행물)] - Novak N / 2009 / New insights into the mechanism and management of allergic diseases : atopic dermatitis / Allergy 64 : 265 ~ 275
[학술지(정기간행물)] - Sebastiani S / 2002 / The role of chemokines in allergic contact dermatitis / Arch Dermatol Res 293 : 552 ~ 559
[학술지(정기간행물)] - Gröne A / 2002 / Keratinocytes and cytokines / Vet Immunol Immunopathol 88 : 1 ~ 12
[학술지(정기간행물)] - Uchi H / 2000 / Cytokines and chemokines in the epidermis / J Dermatol Sci 24 (Suppl. 1) : S29 ~ S38
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UCI(KEPA) : I410-ECN-0101-2018-524-001598789