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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 47 - 55 (9page)
- DOI
- 10.17495/easdl.2018.2.28.1.47
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초록· 키워드
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Prolonged ulcerative colitis (UC) is a major risk factor of colorectal cancer (CRC) in human. Many epidemiological and experimental studies have reported that high protein diet (HPD) intake deteriorates the intestinal environment, which can lead to UC and CRC development. Moreover, we previously showed that feeding HPD dose dependently increased colonic tumor development in a chemical induced mouse colon carcinogenesis model. The mulberry tree (Morus alba L), which is distributed widely in east Asia, has a wide spectrum of biological activities including anti-inflammation and anti-carcinogenesis. In this study, we investigated whether the water extracts of mulberry root bark (MRB) and mulberry twig (MT) could ameliorate the level of colitis in HPD fed mice. Six week-old, male ICR mice were grouped into four groups: control (n=3), dextran sodium sulfate (DSS, n=6), DSS+MRB (n=6), and DSS+MT (n=6). All of the mice were fed HPD (50% casein/kg diet) for 4 weeks. On week 3 of the experimental period, mice in all except the control group, were administrated 3% DSS in drinking water for 5 days to induce colitis. At the same time, MRB (600 mg/kg body weight/day) and MT (5 g/kg body weight/day) was orally administered to mice in the MT and MRB group, respectively, for 5 days. The MRB and MT extracts significantly reduced the disease activity index, mucosal thickness, and level of plasma nitric oxide relative to the DSS group. Additionally, plasma IL-6 and colonic myeloperoxidase activities were significantly reduced by MT and MRB, respectively, compared to the DSS group. However, there were no significant differences in colon length, colon weight, and plasma tumor necrosis factor-α between the DSS and MRB or MT group. Taken together, these results suggest that MRB and MT water extracts can be developed as anti-colitis food components, especially when protein ingestion is increased in human.
목차
ABSTRACT
서론
재료 및 방법
결과 및 고찰
요약 및 결론
REFERENCES
참고문헌 (35)
참고문헌 신청
Byun SY / 2015 / Curcumin ameliorates the tumor-enhancing effects of a high-protein diet in an azoxymethane-induced mouse model of colon carcinogenesis / Nutr Res 35:726~735
Chang LW / 2011 / Antioxidant and antityrosinase activity of mulberry (Morus alba L.) twigs and root bark / Food Chem Toxicol 49:785~790
In-Young Choi / 2011 / Anti-inflammatory effects of Cheongilppong on DSS-induced ulcerative colitis in mice / Oriental Pharmacy and Experimental Medicine 11(1):35~39
최상원 / 2013 / Analysis of Functional Constituents in Mulberry (Morus alba L.) Twigs by Different Cultivars, Producing Areas, and Heat Processings / Preventive Nutrition and Food Science 18(4):256~262
Clapper ML / 2007 / Dextran sulfate sodium-induced colitis-associated neoplasia: a promising model for the development of chemopreventive interventions / Acta Pharmacol Sin 28:1450~1459
Chang LW / 2011 / Antioxidant and antityrosinase activity of mulberry (Morus alba L.) twigs and root bark / Food Chem Toxicol 49:785~790
In-Young Choi / 2011 / Anti-inflammatory effects of Cheongilppong on DSS-induced ulcerative colitis in mice / Oriental Pharmacy and Experimental Medicine 11(1):35~39
최상원 / 2013 / Analysis of Functional Constituents in Mulberry (Morus alba L.) Twigs by Different Cultivars, Producing Areas, and Heat Processings / Preventive Nutrition and Food Science 18(4):256~262
Clapper ML / 2007 / Dextran sulfate sodium-induced colitis-associated neoplasia: a promising model for the development of chemopreventive interventions / Acta Pharmacol Sin 28:1450~1459
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UCI(KEPA) : I410-ECN-0101-2018-594-001831767