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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Silver (Ag) has been widely used in commercial products and medical fields since ancient times because of its antibacterial effect. It is harmless and non-toxic to the human body. For this reason, recent research has actively evaluated antimicrobial activity using silver (Ag). In this study, we investigated the inhibitory effect of a silver-based compound, silver phosphate (Ag₃PO₄) on the growth of Staphylococcus aureus and the activation of human immunity. First, the inhibitory effect of Ag₃PO₄ on the growth of Staphylococcus aureus was confirmed by a growth curve and a colonyounting method. As a result, the growth inhibitory effect increased as the concentration of Ag₃PO₄ increased. Specifically, treatment with 5 μg/mL of Ag₃PO₄ resulted in no bacteria growth, and the colony-counting method showed a remarkable inhibition. In addition, the expression of cytokine IL-8 by Ag₃PO₄ was examined to investigate the cellular immune system activation by Ag₃PO₄. After pretreatment of Staphylococcus aureus for 1 hour with 50 μg/mL Ag₃PO₄, an increased IL-8 mRNA expression resulted. In cells treated with Ag₃PO₄, we found that the expression of IL-8 was enhanced in a time-dependent fashion compared to non-treated cells. These results indicate that Ag₃PO₄ induces antimicrobial activity against Staphylococcus aureus and activates human immunity. These results are expected to contribute to the future study of the mechanism of silver (Ag) and silver-based compounds in relation to antibacterial activity.
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REFERENCES
참고문헌 (12)
참고문헌 신청
[학술지(정기간행물)] - Chen M / 2011 / Antimicrobial activity and the mechanism of silver nanoparticle thermosensitive gel / Int J Nanomedicine 6 : 2873 ~ 2877
[학술지(정기간행물)] - Eckmann L / 1993 / Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry / Infect Immun 61 : 4569 ~ 4574
[학술지(정기간행물)] - Elewaut D / 1999 / $NF-{\kappa}B$ is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria / J Immunol 163 : 1457 ~ 1466
[학술지(정기간행물)] - Gurusamy KS / 2013 / Antibiotic therapy for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in surgical wounds / The Cochrane Database of Systematic Reviews 8
[학술지(정기간행물)] - Kim JM / 1998 / Apoptosis of human intestinal epithelial cells after bacterial invasion / J Clin Invest 102 : 1815 ~ 1823
[학술지(정기간행물)] - Eckmann L / 1993 / Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry / Infect Immun 61 : 4569 ~ 4574
[학술지(정기간행물)] - Elewaut D / 1999 /
[학술지(정기간행물)] - Gurusamy KS / 2013 / Antibiotic therapy for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in surgical wounds / The Cochrane Database of Systematic Reviews 8
[학술지(정기간행물)] - Kim JM / 1998 / Apoptosis of human intestinal epithelial cells after bacterial invasion / J Clin Invest 102 : 1815 ~ 1823
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UCI(KEPA) : I410-ECN-0101-2018-510-001903451