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논문 기본 정보

자료유형
학술저널
저자정보
Sunfang Chen (Department of Orthopedics the First Afliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)) Dan Cai (Department of Orthopedics the First People’s Hospital of Huzhou First Afliated Hospital of Huzhou University) Qi Dong (Department of Orthopedics Honghui Hospital Xi’an Jiao Tong University) Gaoxiang Ma (Department of Orthopedics the Central Hospital Afliated to Shaoxing University) Chennan Xu (Department of Orthopedics the Central Hospital Afliated to Shaoxing University) Xiaogang Ba (Department of Orthopedics The Spine Surgical Center Second Afliated Hospital of Naval Medical University) Wei Yuan (Department of Orthopedics Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine) Bing Wu (Department of Orthopedics the Central Hospital Afliated to Shaoxing University) Bin Fang (Department of Orthopedics the First Afliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine))
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
2,052 - 2,070 (19page)
DOI
https://doi.org/10.1186/s40824-023-00428-0

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BackgroundThe reconstruction of tendons with large defects requires grafts with high mechanical strength and is often hindered by complications such as infection and adhesion. Hence, grafts combining the advantages of mechanical resilience and antibacterial/antiadhesion activity are highly sought after. MethodsThe silver nanoparticles (GA-Ag NPs) synthesized from gallic acid and silver nitrate were attached to a decellularized extracellular matrix (Decellularized Tendon crosslinking GA-AgNPs, DT-Ag). We examined the histological structure, mechanical property, morphology, Zeta potential, cytotoxicity, antibacterial properties, antioxidant and anti-inflammatory properties, and ability of the DT-Ag to treat tendon defects in animals. ResultsApproximately 108.57 ± 0.94 μg GA-Ag NPs loaded per 50 mg DT, the cross-linked part of GA-Ag NPs was 65.47 ± 0.57%, which provided DT-Ag with long-lasting antibacterial activity. Meanwhile, GA endowed DT-Ag with good antioxidant and anti-inflammatory activities. Additionally, The DT-Ag facilitated M2 macrophage polarization, and suppressed fibrin deposition by hindering fibroblast adhesion. Mormore, the main advantages of DT-Ag, namely its long-lasting antibacterial activity (tested using Escherichia coli and Staphylococcus aureus as models) and the ability to prevent tissue adhesion were confirmed in vivo. ConclusionThe fabricated multifunctional tendon graft was highly hydrophilic, biocompatible, and mechanically resilient, and concluded to be well suited for dealing with the main complications of surgical tendon reconstruction and has bright application prospects.

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