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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 438 - 443 (6page)
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초록· 키워드
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Background: Pattern hair loss is a very common problem.
Although effective therapeutics for the treatment of pattern hair loss have been used, novel therapeutic modalities are still required to enhance hair growth. Objective: We investigated the efficacy and safety of a complex (ALAVAX) of 5-aminolevulinic acid (5-ALA) and glycyl-histidyl-lysine (GHK) peptide for the treatment of pattern hair loss. Methods: Forty-five patients with male pattern hair loss were treated with ALAVAX 100 mg/ml (group A), ALAVAX 50 mg/ml (group B) or placebo (group C) once a day for 6 months. Total hair count, hair length, hair thickness, patient’s assessment and adverse events were evaluated at month 1, 3, and 6.
Results: An increase in hair count for 6 months was 52.6 (p＜0.05) in group A, 71.5 (p＜0.05) in group B, and 9.6 in group C. The ratio of changes in hair count between group B (2.38) and group C (1.21) at 6 months showed a statistically significant difference (p＜0.05). The proportion above good satisfaction was higher in group A (26.7%) than in the other groups (group B: 14.3%, group C: 7.1%). There was no statistically significant difference in hair length and hair thickness among 3 groups at 6 months. There was no adverse event in 3 groups. Conclusion: Our study showed that a complex of 5-ALA and GHK peptide may be considered as one of the complementary agents for the treatment of male pattern hair loss.
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참고문헌 (13)
참고문헌 신청
Sung Hyub Han / 2012 / Quality of Life Assessment in Male Patients with Androgenetic Alopecia: Result of a Prospective, Multicenter Study / Annals of Dermatology 24(3):311~318
Schweiger ES. / 2010 / Update on the pathogenesis, genetics and medical treatment of patterned hair loss / J Drugs Dermatol 9:1412~1419
Olsen EA. / 2006 / Dutasteride Alopecia Research Team. The importance of dual 5alpha-reductase inhibition in the treatment of mal. pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride / J Am Acad Dermatol 55:1014~1023
Munck A. / 2014 / Use of low-level laser therapy as monotherapy or concomitant therapy for mal. and femal. androgenetic alopecia / Int J Trichology 6:45~49
Hyun Keol Pyo / 2007 / The Effect of Tripeptide-Copper Complex on Human Hair Growth In Vitro / Archives of Pharmacal Research 30(7):834~839
Schweiger ES. / 2010 / Update on the pathogenesis, genetics and medical treatment of patterned hair loss / J Drugs Dermatol 9:1412~1419
Olsen EA. / 2006 / Dutasteride Alopecia Research Team. The importance of dual 5alpha-reductase inhibition in the treatment of mal. pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride / J Am Acad Dermatol 55:1014~1023
Munck A. / 2014 / Use of low-level laser therapy as monotherapy or concomitant therapy for mal. and femal. androgenetic alopecia / Int J Trichology 6:45~49
Hyun Keol Pyo / 2007 / The Effect of Tripeptide-Copper Complex on Human Hair Growth In Vitro / Archives of Pharmacal Research 30(7):834~839
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